The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes.
The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes.
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晚期糖基化终末产物可溶性受体（sCRP）作为疾病风险和不良结局的潜在生物标志物的用途。
DOI：
10.1016/j.redox.2021.101958
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发表时间：
2021-06
期刊：
影响因子：
11.4
通讯作者：
Erusalimsky JD
中科院分区：
文献类型：
--
作者：
Erusalimsky JD
晚期糖基化终产物的可溶性受体（sRAGE）一直被认为是促炎RAGE配体的汇，因此与炎症应激和疾病的保护有关。另一种并非相互排斥的观点是，循环中高水平的sRAGE反映了细胞表面RAGE的过度刺激，如果持续，会导致促炎过程的放大和病理状态的恶化。考虑到这两种情况，本综述的重点是sRAGE作为疾病风险和不良后果的前瞻性生物标志物的潜在作用。测定血液中sRAGE水平的预后价值存在争议。sRAGE水平升高可能是由于细胞表面RAGE的过度刺激。sRAGE的升高可能反映了慢性炎症和多病，而不是健康状态。sRAGE是一种很有前景的疾病风险和不良后果的生物标志物。
The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease. An alternative, though not mutually exclusive view is that high levels of sRAGE in circulation reflect the overstimulation of cell surface RAGE which if persistent, lead to the amplification of pro-inflammatory processes and the exacerbation of pathological states. With these two scenarios in mind this review focuses on the potential role of sRAGE as a prospective biomarker of disease risk and adverse outcomes. The prognostic value of measuring sRAGE levels in blood is subjected to debate. Raised sRAGE levels may result from the overstimulation of cell surface RAGE. Raised sRAGE may reflect chronic inflammation and multimorbidity rather than a healthy state. sRAGE is a promising biomarker of disease risk and adverse outcomes.
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