Towards a 'systems'-level understanding of the nervous system and its disorders.
Towards a 'systems'-level understanding of the nervous system and its disorders.
复制标题
DOI：
10.1016/j.tins.2013.07.003
复制
发表时间：
2013-11
影响因子：
15.9
通讯作者：
Mehler MF
中科院分区：
文献类型：
--
作者：
Qureshi IA;Mehler MF
It is becoming clear that nervous system development and adult functioning are highly coupled with other physiological systems. Accordingly, neurological and psychiatric disorders are increasingly being associated with a range of systemic co-morbidities including, most prominently, impairments in immunological and bio-energetic parameters as well as in the gut microbiome. Here, we discuss various aspects of the dynamic crosstalk between these systems that underlies nervous system development, homeostasis, and plasticity. We believe a better definition of this underappreciated systems physiology will yield important insights into how nervous system diseases with systemic co-morbidities arise and potentially identify novel diagnostic and therapeutic strategies.
登录
查看更多内容
DOI：
10.1126/science.1209870
发表时间：
2011-11-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Czupryn A;Zhou YD;Chen X;McNay D;Anderson MP;Flier JS;Macklis JD
通讯作者：
Macklis JD
影响因子：
3.7
作者：
Fathi A;Hatami M;Hajihosseini V;Fattahi F;Kiani S;Baharvand H;Salekdeh GH
通讯作者：
Salekdeh GH
影响因子：
16.2
作者：
Cowley, MA;Smith, RG;Horvath, TL
通讯作者：
Horvath, TL
影响因子：
16.2
作者：
Datwani, Akash;McConnell, Michael J.;Kanold, Patrick O.;Micheva, Kristina D.;Busse, Brad;Shamloo, Mehrdad;Smith, Stephen J.;Shatz, Carla J.
通讯作者：
Shatz, Carla J.
影响因子：
2.9
作者：
Bouret, Sebastien G.
通讯作者：
Bouret, Sebastien G.