The oblique muscle organizer in Hirudo medicinalis, an identified embryonic cell projecting multiple parallel growth cones in an orderly array.
The oblique muscle organizer in Hirudo medicinalis, an identified embryonic cell projecting multiple parallel growth cones in an orderly array.
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药用水蛭中的斜肌组织者，一种已鉴定的胚胎细胞，投射出多个有序排列的平行生长锥。
DOI：
10.1016/0012-1606(91)90342-z
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发表时间：
1991
影响因子：
2.7
通讯作者：
KristanJr,WB
中科院分区：
文献类型：
--
作者：
Jellies,J;KristanJr,WB
The oblique muscle layer in the leech body wall is built upon the processes of a unique identified embryonic cell, the Comb- or C-cell. Each C-cell is composed of a spindle-shaped soma that projects approximately 70 parallel processes through the developing body wall at an angle oblique to the long axis. The morphogenesis of this cell and the navigation of its growth cones were examined by intracellular dye filling and antibody staining. At the earliest stages described each C-cell had about six processes, with those near the center of the cell oriented obliquely. As processes were added at the axial ends of the soma they often projected along previously developed longitudinal or circular muscle founder cells and then secondarily aligned themselves parallel to the older processes from the same C-cell. All growth cones initially extended to a particular location in the body wall, where they ceased growing until all 70 processes had been added (over the course of about 5 days). As adjacent segmental homologs met, their growth cones intermingled, eventually sorting out to align parallel. When one of these cells was ablated early—but not later—in development, the remaining adjacent segmental homologs expanded into the vacant territory, consistent with a hypothesis of mutual avoidance between segmental homologs. Most processes that expanded into the experimentally induced vacancy remained correctly oriented and parallel; the few exceptions projected instead along the mirror-image trajectory. Thus, expression of specific avoidance between adjacent C-cell processes is developmentally regulated and functions as a guidance mechanismin vivo, in that it serves to restrict possible trajectories. After aligning its growth cones, each cell stopped adding processes and the processes rapidly extended in concert along relatively precise trajectories. Processes of contralateral homologs cross to form the orthogonal grid used as a scaffold by myocytes to form the oblique muscles. The advancing fronts of growth cones reached the dorsal midline at about the same time as body closure occurs (at about Embryonic Day 20) at which time the C-cells became granular, lost processes, and presumably died. This sequence of developmental events is consistent with temporal and spatial regulation of different morphogenetic strategies, including—but not limited to—specific avoidance, and further suggests testable hypotheses of mechanisms of growth cone navigation in the intact embryo.
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影响因子：
4.2
作者：
N. Patel;Z. Xie;S. H. Young;M. Poo
通讯作者：
M. Poo
影响因子：
2.7
作者：
Torrence,SA;Law,MI;Stuart,DK
通讯作者：
Stuart,DK
影响因子：
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作者：
LANDMESSER, L;DAHM, L;RUTISHAUSER, U
通讯作者：
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培养物中不同神经组织生长的生长锥和神经突之间的相互作用
影响因子：
5.3
作者：
J. Kapfhammer;J. Raper
通讯作者：
J. Raper
DOI：
10.1523/jneurosci.06-02-00364.1986
发表时间：
1986-02
期刊：
--
影响因子：
--
作者：
M. Caudy;D. Bentley
通讯作者：
M. Caudy;D. Bentley