Chronic Intracortical Recording and Electrochemical Stability of Thiol-ene/Acrylate Shape Memory Polymer Electrode Arrays.
Chronic Intracortical Recording and Electrochemical Stability of Thiol-ene/Acrylate Shape Memory Polymer Electrode Arrays.
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DOI：
10.3390/mi9100500
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发表时间：
2018-09-29
期刊：
影响因子：
3.4
通讯作者：
Black BJ
中科院分区：
文献类型：
--
作者：
Stiller AM;Usoro J;Frewin CL;Danda VR;Ecker M;Joshi-Imre A;Musselman KC;Voit W;Modi R;Pancrazio JJ;Black BJ
由于植入器械的功能寿命短，目前的皮质内探针技术在临床应用中受到限制。装置通常在植入后数月至数年失效，可能是由于以神经胶质瘢痕形成和神经元死亡为特征的慢性免疫反应。已经证明，这种神经炎症反应受到刚性器械和软脑组织之间的机械不匹配的影响，从而激发了使用较软聚合物材料进行探针封装的兴趣。在这里，我们证明了稳定的记录和电化学性能获得完全封装的形状记忆聚合物（SMP）皮质内电极植入大鼠运动皮层13周。SMP是一类在暴露于特定条件时表现出模量变化的材料。与其干燥的室温模量约2 GPa相比，这些器械中使用的制剂在植入后软化了一个数量级。
Current intracortical probe technology is limited in clinical implementation due to the short functional lifetime of implanted devices. Devices often fail several months to years post-implantation, likely due to the chronic immune response characterized by glial scarring and neuronal dieback. It has been demonstrated that this neuroinflammatory response is influenced by the mechanical mismatch between stiff devices and the soft brain tissue, spurring interest in the use of softer polymer materials for probe encapsulation. Here, we demonstrate stable recordings and electrochemical properties obtained from fully encapsulated shape memory polymer (SMP) intracortical electrodes implanted in the rat motor cortex for 13 weeks. SMPs are a class of material that exhibit modulus changes when exposed to specific conditions. The formulation used in these devices softens by an order of magnitude after implantation compared to its dry, room-temperature modulus of ~2 GPa.
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影响因子：
4
作者：
Barrese JC;Aceros J;Donoghue JP
通讯作者：
Donoghue JP
影响因子：
4.1
作者：
Do DH;Ecker M;Voit WE
通讯作者：
Voit WE
影响因子：
14
作者：
Karumbaiah, Lohitash;Norman, Sharon E.;Bellamkonda, Ravi V.
通讯作者：
Bellamkonda, Ravi V.
影响因子：
13.6
作者：
Luan L;Wei X;Zhao Z;Siegel JJ;Potnis O;Tuppen CA;Lin S;Kazmi S;Fowler RA;Holloway S;Dunn AK;Chitwood RA;Xie C
通讯作者：
Xie C
DOI：
10.3389/neuro.16.018.2009
发表时间：
2010
期刊：
Frontiers in neuroengineering
影响因子：
--
作者：
Leach JB;Achyuta AK;Murthy SK
通讯作者：
Murthy SK