Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis.
Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis.
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DOI：
10.1093/ije/dyaa183
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发表时间：
2021-07-09
影响因子：
7.7
通讯作者：
Davey Smith G
中科院分区：
文献类型：
--
作者：
Anderson EL;Richmond RC;Jones SE;Hemani G;Wade KH;Dashti HS;Lane JM;Wang H;Saxena R;Brumpton B;Korologou-Linden R;Nielsen JB;Åsvold BO;Abecasis G;Coulthard E;Kyle SD;Beaumont RN;Tyrrell J;Frayling TM;Munafò MR;Wood AR;Ben-Shlomo Y;Howe LD;Lawlor DA;Weedon MN;Davey Smith G
已确定阿尔茨海默病（AD）患者经历睡眠中断。然而，睡眠的数量、质量或时间的中断是否是AD发作的风险因素仍然未知。我们使用了最大的已发表的关于自我报告和加速计测量的睡眠特征（时钟类型，持续时间，碎片，失眠，白天小睡和白天嗜睡）和AD的全基因组关联研究。孟德尔随机化（MR）被用来评估自我报告和加速度计测量的睡眠参数对AD风险的因果关系。总体而言，几乎没有证据支持睡眠特征对AD风险的因果关系。有一些提示性证据表明，自我报告的日间小睡与较低的AD风险相关[比值比（OR）：0.70，95%置信区间（CI）：0.50-0.99）。其他一些睡眠特征（加速度计测量的“晚上”和睡眠时间，以及自我报告的白天嗜睡）与白天小睡的OR值相似，但估计得不太精确。总的来说，我们发现非常有限的证据支持睡眠特征对AD风险的因果关系。我们的研究结果提供了初步证据，白天小睡可以降低AD风险。鉴于这是第一个关于AD风险的多个自我报告和客观睡眠特征的MR研究，当这些数据可用时，应使用独立样本复制研究结果。
It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. We used the largest published genome-wide association studies of self-reported and accelerometer-measured sleep traits (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness), and AD. Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters on AD risk. Overall, there was little evidence to support a causal effect of sleep traits on AD risk. There was some suggestive evidence that self-reported daytime napping was associated with lower AD risk [odds ratio (OR): 0.70, 95% confidence interval (CI): 0.50–0.99). Some other sleep traits (accelerometer-measured ‘eveningness’ and sleep duration, and self-reported daytime sleepiness) had ORs of a similar magnitude to daytime napping, but were less precisely estimated. Overall, we found very limited evidence to support a causal effect of sleep traits on AD risk. Our findings provide tentative evidence that daytime napping may reduce AD risk. Given that this is the first MR study of multiple self-report and objective sleep traits on AD risk, findings should be replicated using independent samples when such data become available.
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影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
DOI：
10.1097/ede.0000000000000161
发表时间：
2014-11
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Burgess S;Davies NM;Thompson SG;EPIC-InterAct Consortium
通讯作者：
EPIC-InterAct Consortium
影响因子：
7.7
作者：
Burgess, Stephen;Thompson, Simon G.
通讯作者：
Thompson, Simon G.