Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye.
Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye.
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DOI：
10.1002/dvdy.22033
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发表时间：
2009-09
影响因子：
2.5
通讯作者：
Zacharias, Amanda L.
中科院分区：
文献类型：
--
作者：
Gage, Philip J.;Zacharias, Amanda L.
组织间的细胞外信号“串扰”是许多器官发育的重要要求，但其潜在机制通常仍知之甚少。眼睛的前段由四个胚胎谱系构成，提供了一个独特的机会来从遗传学上剖析发育过程，如信号“串扰”，而不必担心诱导致命性。在当前的综述中，我们总结了最近的数据表明，PITX 2，同源结构域转录因子，整合视黄酸和经典的Wnt/β-catenin信号在眼前节发育。由于视黄酸信号传导、经典Wnt/β-连环蛋白信号传导和PITX 2的需求不是眼睛所独有的，因此这种新鉴定的途径可能在发育期间的其他地方和组织稳态中具有相关性。
Extracellular signaling “cross-talk” between tissues is an important requirement for development of many organs yet the underlying mechanisms generally remain poorly understood. The anterior segment of the eye, which is constructed from four embryonic lineages, provides a unique opportunity to genetically dissect developmental processes such as signaling “cross-talk” without fear of inducing lethality. In the current review, we summarize recent data showing that PITX2, a homeodomain transcription factor, integrates retinoic acid and canonical Wnt/β-catenin signaling during anterior segment development. Because the requirements for retinoic acid signaling, canonical Wnt/β-catenin signaling, and PITX2 are not unique to the eye, this newly identified pathway may have relevance elsewhere during development and in tissue homeostasis.
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