Spatial orientation in Drosophila
Spatial orientation in Drosophila
复制标题
果蝇的空间定向
DOI：
10.1080/01677060802441364
复制
发表时间：
2009
影响因子：
1.9
通讯作者：
T. Zars
中科院分区：
文献类型：
--
作者：
T. Zars
翻译后摘要：空间取向是至关重要的许多行为。定向状态的本质是相对于一个或多个地标的过去、现在和未来空间位置的知识。动物是如何如此流畅地解决这个问题的？对相对简单的生物体的研究可能有助于确定定向机制。两种可能使用路径整合作为方向的主要输入的行为--位置学习和持续的目标选择--允许检查果蝇的细胞和神经回路机制。虽然我们对这些过程的理解仍然相对不成熟，但最近的一些发现为支持定向的机制提供了见解。首先，位置学习提供了很好的访问过去，现在和未来方面的方向，但目前是不太开放的理解如何苍蝇建立一个关系的地标。学习后的行为变化是远离和避免预测会惩罚苍蝇的地方的方向，包括方向的所有时间方面，并且可以持续几分钟到几个小时。这一结论得到了几种学习现象的支持。第二，持续的目标选择提供了对确定与地标的关系的过程的最佳访问。使用一个消失的视觉地标范例，持续的目标选择被证明需要一个秒长的“路径整合记忆”的中央复合体的部分。在这个短时间尺度上，路径整合记忆与持续时间更长的地点记忆是如何联系的，目前还不清楚。然而，对位置学习和持续目标选择的研究可能会提供对简单大脑中定向机制的见解。
Abstract: Spatial orientation is critical for many behaviors. Intrinsic to the oriented state is the knowledge of past, present, and future spatial location relative to one or more landmarks. How do animals so fluidly solve this problem? Determining mechanisms of orientation may benefit from investigation of relatively simple organisms. Two behaviors that presumably use path integration as a major input to orientation—place learning and persistent target selection—allow for the examination of cellular and neural circuit mechanisms in Drosophila. Although our understanding of these processes is still relatively immature, some recent findings provide insights into the mechanisms supporting orientation. First, place learning provides good access to the past, present, and future aspects of orientation, but currently is less open to understanding how a fly establishes a relationship to landmarks. The change in behavior after learning is orientation away from, and avoiding, a place predicted to punish a fly, incorporating all temporal aspects of orientation, and can last for minutes to hours. This conclusion is supported by several learning phenomena. Second, persistent target selection provides the best access to the processes determining relationships to landmarks. Using a disappearing visual-landmark paradigm, persistent target selection was shown to require parts of the central complex for a seconds-long “path integration memory.” How the path integration memory, on this short time scale, is related to longer lasting place memories is, as yet, unknown. Nevertheless, studies of place learning and persistent target selection may provide insights into orientation mechanisms in a simple brain.
DOI：
10.1073/pnas.93.12.6079
发表时间：
1996-06-11
影响因子：
11.1
作者：
Sayeed, O;Benzer, S
通讯作者：
Benzer, S
DOI：
10.1002/neu.10185
发表时间：
2003-03-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Friggi-Grelin, F;Coulom, H;Birman, S
通讯作者：
Birman, S