Impact of N-Linked Glycosylation on Therapeutic Proteins.
Impact of N-Linked Glycosylation on Therapeutic Proteins.
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DOI：
10.3390/molecules27248859
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发表时间：
2022-12-13
期刊：
影响因子：
--
通讯作者：
Tan Z
中科院分区：
文献类型：
--
作者：
Chen B;Liu W;Li Y;Ma B;Shang S;Tan Z
与小分子药物相比，治疗性蛋白质在治疗各种疾病方面具有独特的优势，如靶点特异性更高、药理功效更强、副作用相对较低。这些优势使其在药物开发和临床实践中越来越受到重视。然而，尽管其价值很高，但其物理、化学和药理学性质的内在局限性往往限制了其更广泛的应用。糖基化作为最重要的翻译后修饰之一，已被证明对蛋白质的许多性质产生积极影响，包括分子稳定性以及药效学和药代动力学特征。糖工程，其中涉及改变蛋白质的糖基化模式，因此预计是一种有效的手段，克服治疗性蛋白质的问题。在这篇综述中，我们总结了最近的努力和进展的糖工程促红细胞生成素和IgG单克隆抗体，说明这一战略的重要性，在提高治疗性蛋白质的性能，并提供一个简要概述糖工程是如何应用于蛋白质为基础的药物的目标。
Therapeutic proteins have unique advantages over small-molecule drugs in the treatment of various diseases, such as higher target specificity, stronger pharmacological efficacy and relatively low side effects. These advantages make them increasingly valued in drug development and clinical practice. However, although highly valued, the intrinsic limitations in their physical, chemical and pharmacological properties often restrict their wider applications. As one of the most important post-translational modifications, glycosylation has been shown to exert positive effects on many properties of proteins, including molecular stability, and pharmacodynamic and pharmacokinetic characteristics. Glycoengineering, which involves changing the glycosylation patterns of proteins, is therefore expected to be an effective means of overcoming the problems of therapeutic proteins. In this review, we summarize recent efforts and advances in the glycoengineering of erythropoietin and IgG monoclonal antibodies, with the goals of illustrating the importance of this strategy in improving the performance of therapeutic proteins and providing a brief overview of how glycoengineering is applied to protein-based drugs.
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