Additive effects of orexin B and vasoactive intestinal polypeptide on LL-37-mediated antimicrobial activities.
Additive effects of orexin B and vasoactive intestinal polypeptide on LL-37-mediated antimicrobial activities.
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DOI：
10.1016/j.jneuroim.2010.11.009
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发表时间：
2011-04
影响因子：
3.3
通讯作者：
Kawai, Toshihisa
中科院分区：
文献类型：
--
作者：
Ohta, Kouji;Kajiya, Mikihiko;Zhu, Tongbo;Nishi, Hiromi;Mawardi, Hani;Shin, Jane;Elbadawi, Leena;Kamata, Nobuyuki;Komatsuzawa, Hitoshi;Kawai, Toshihisa
本研究检测了食欲素 B (ORXB) 和血管活性肠肽 (VIP) 单独或与阳离子抗菌肽（如 LL-37）联合使用对大肠杆菌、铜绿假单胞菌、变形链球菌和金黄色葡萄球菌的杀菌作用。在低 NaCl 浓度下检测到单独的 ORXB 或 VIP 的杀菌效果，但在生理 NaCl 浓度（150 mM）下减弱。然而，ORXB 和 VIP 在 150 mM NaCl 中的这种减弱的杀菌活性通过添加 LL-37 得以恢复。因此，我们的结果表明，VIP 和 ORXB 似乎在粘膜组织的生理环境中与 LL-37 协同介导杀菌作用。
The present study examined the bactericidal effects of Orexin B (ORXB) and vasoactive intestinal peptide (VIP) alone or combined with cationic antimicrobial peptides, such as LL-37, on Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans and Staphylococcus aureus. The bactericidal effect of ORXB or VIP alone was detected in low NaCl concentration, but attenuated in physiological NaCl concentration (150 mM). However, such attenuated bactericidal activities of ORXB and VIP in 150 mM NaCl were regained by adding LL-37. Therefore, our results indicate that VIP and ORXB appear to mediate bactericidal effects in concert with LL-37 in the physiological context of mucosal tissue.
影响因子：
8.6
作者：
Wang, Xinran;Ouyang, Yijian;Dai, Hongjie
通讯作者：
Dai, Hongjie