Depression and wish to die in a multicenter cohort of ALS patients.
Depression and wish to die in a multicenter cohort of ALS patients.
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DOI：
10.3109/21678421.2014.980428
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发表时间：
2015-06
影响因子：
2.8
通讯作者：
Als Cosmos Study Group
中科院分区：
文献类型：
--
作者：
Rabkin JG;Goetz R;Factor-Litvak P;Hupf J;McElhiney M;Singleton J;Mitsumoto H;Als Cosmos Study Group
To determine prevalence of depressive disorders and wish to die at the baseline visit of a longitudinal multi-site study of patients with ALS. Structured telephone interviews were conducted with patients diagnosed in past 18 months at 16 U.S. ALS centers. Demographic, medical, psychiatric and other psychological measures were administered. Of 329 patients assessed, mean ALSFRS-R score was 36.6; 88% (289/329) had no depressive disorder, 7% (24/329)had minor depression, and 5% (16/329)had current major depressive disorder (DSM-IV criteria). Demographic, financial and employment factors were unrelated to depression, as were duration of ALS symptoms and respiratory status, although depressed patients had lower scores on the total ALSFRS-R ( p = .004) and gross motor function (p<.001). Depressed patients reported less pleasure, greater suffering, weariness and anxiety, more stress, were less hopeful, felt less control over illness management, reported lower quality of life, more often had thoughts about ending their lives and hastening death (all p<.001). Of the 62 patients (19% of the sample) who expressed a wish to die, only 37% (23/62) were clinically depressed. Depressive disorders are not only to be expected of ALS patients. Wish to die is not always expressed in the context of depression and does not necessarily represent psychopathology as such.
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ALS多中心队列氧化应激研究（ALS Cosmos）：研究方法，招募和基线人口统计学和疾病特征。
DOI：
10.3109/21678421.2013.864312
发表时间：
2014-06
影响因子：
2.8
作者：
Mitsumoto H;Factor-Litvak P;Andrews H;Goetz RR;Andrews L;Rabkin JG;McElhiney M;Nieves J;Santella RM;Murphy J;Hupf J;Singleton J;Merle D;Kilty M;Heitzman D;Bedlack RS;Miller RG;Katz JS;Forshew D;Barohn RJ;Sorenson EJ;Oskarsson B;Fernandes Filho JA;Kasarskis EJ;Lomen-Hoerth C;Mozaffar T;Rollins YD;Nations SP;Swenson AJ;Shefner JM;Andrews JA;Koczon-Jaremko BA;ALS COSMOS Study Group
通讯作者：
ALS COSMOS Study Group
DOI：
10.3109/17482960903544576
发表时间：
2010-05-03
期刊：
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
影响因子：
--
作者：
Huey ED;Koppel J;Armstrong N;Grafman J;Floeter MK
通讯作者：
Floeter MK
影响因子：
6
作者：
Kurt, Anja;Nijboer, Femke;Kuebler, Andrea
通讯作者：
Kuebler, Andrea
影响因子：
9.9
作者：
Lou, JS;Reeves, A;Sexton, G
通讯作者：
Sexton, G
影响因子：
--
作者：
Averill, Alyssa J.;Kasarskis, Edward J.;Segerstrom, Suzanne C.
通讯作者：
Segerstrom, Suzanne C.