Familial limb pain and migraine: 8-year follow-up of four generations.
Familial limb pain and migraine: 8-year follow-up of four generations.
复制标题
DOI：
10.1177/0333102415620906
复制
发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Guiloff RJ
中科院分区：
文献类型：
--
作者：
Angus-Leppan H;Guiloff RJ
成人和儿童的偏头痛肢体疼痛可能未被充分认识。关于这种疾病的家族形式的信息很少。描述四代人以来家族性偏头痛肢体疼痛的临床和遗传模式，并回顾肢体疼痛作为偏头痛表现的证据。对 27 名家庭成员进行 8 年随访的前瞻性临床和谱系分析。该家族有八名成员患有良性复发性肢体疼痛，并伴有显性遗传模式的头痛。头痛发生在头痛之前、期间或之后，可能或明确有先兆偏头痛、无先兆偏头痛和下半部头痛。六名患者的肢体疼痛符合国际头痛协会的先兆标准，三名患者的肢体疼痛也没有头痛。家庭中有四名成员在童年时期患有反复腹痛和/或晕动病。这是第一份关于显性家族性肢体疼痛与偏头痛暂时相关的报告，该疼痛从成年期开始或从儿童期开始并持续到成年期。指示了对遗传标记的搜索。肢体疼痛应被视为与偏头痛相关的儿童周期性综合征，并被视为成人偏头痛谱系的一部分。
Migraine limb pain may be under-recognized in adults and children. There is little information about familial forms of this disorder. To describe the clinical and inheritance patterns of familial migraine limb pain over four generations and to review the evidence for limb pain as a manifestation of migraine. Prospective clinical and pedigree analysis with an 8-year follow-up of 27 family members. Eight members of the family had benign recurrent limb pain associated with headache in a dominant inheritance pattern. Limb pain occurred before, during or after the headache, with probable or definite migraine with aura, migraine without aura and lower-half headache. The limb pain fulfilled the International Headache Society criteria for aura in six patients and also occurred without headache in three. Four members of the family had recurrent abdominal pain and/or motion sickness in childhood. This is the first report of dominant familial limb pain temporally associated with migraine headache, starting in adulthood or starting in childhood and continuing into adulthood. A search for a genetic marker is indicated. Limb pain should be included as a childhood periodic syndrome linked to migraine and recognized as part of the migraine spectrum in adults.
登录
查看更多内容
DOI：
10.3988/jcn.2012.8.2.89
发表时间：
2012-06
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Bernstein C;Burstein R
通讯作者：
Burstein R
影响因子：
4.9
作者：
Alvarez, Monica;Montojo, Teresa;Pareja, Juan A.
通讯作者：
Pareja, Juan A.
影响因子：
5.2
作者：
AbuArafeh, I;Russell, G
通讯作者：
Russell, G
DOI：
10.1111/j.1468-2982.2008.01794.x
发表时间：
2009-07-01
期刊：
Cephalalgia : an international journal of headache
影响因子：
--
作者：
Riederer, F;Selekler, H M;Wober, C
通讯作者：
Wober, C
影响因子：
4.9
作者：
ANGUSLEPPAN, H;OLAUSSON, B;LAMBERT, GA
通讯作者：
LAMBERT, GA