Endoplasmic Reticulum Stress, Oxidative Stress, and Rheumatic Diseases.
Endoplasmic Reticulum Stress, Oxidative Stress, and Rheumatic Diseases.
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DOI：
10.3390/antiox11071306
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发表时间：
2022-06-29
期刊：
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Background: The endoplasmic reticulum (ER) is a multi-functional organelle responsible for cellular homeostasis, protein synthesis, folding and secretion. It has been increasingly recognized that the loss of ER homeostasis plays a central role in the development of autoimmune inflammatory disorders, such as rheumatic diseases. Purpose/Main contents: Here, we review current knowledge of the contribution of ER stress to the pathogenesis of rheumatic diseases, with a focus on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We also review the interplay between protein folding and formation of reactive oxygen species (ROS), where ER stress induces oxidative stress (OS), which further aggravates the accumulation of misfolded proteins and oxidation, in a vicious cycle. Intervention studies targeting ER stress and oxidative stress in the context of rheumatic diseases are also reviewed. Conclusions: Loss of ER homeostasis is a significant factor in the pathogeneses of RA and SLE. Targeting ER stress, unfolded protein response (UPR) pathways and oxidative stress in these diseases both in vitro and in animal models have shown promising results and deserve further investigation.
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影响因子：
3.6
作者：
Ahmadiany, Mahdieh;Alavi-Samani, Mahshid;Rahmati, Marveh
通讯作者：
Rahmati, Marveh
影响因子：
2.7
作者：
Choi Y;Jung JH;Lee EG;Kim KM;Yoo WH
通讯作者：
Yoo WH
影响因子：
4.4
作者：
Corrigall, VM;Bodman-Smith, MD;Panayi, GS
通讯作者：
Panayi, GS
影响因子：
4.9
作者：
Baka Z;Buzás E;Nagy G
通讯作者：
Nagy G
DOI：
10.1038/nrm3588
发表时间：
2013-06
期刊：
Nature reviews. Molecular cell biology
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