Estradiol modulates the anorexic response to central glucagon-like peptide 1.
Estradiol modulates the anorexic response to central glucagon-like peptide 1.
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DOI：
10.1016/j.yhbeh.2017.05.012
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发表时间：
2017-07
影响因子：
3.5
通讯作者：
Williams DL
中科院分区：
文献类型：
--
作者：
Maske CB;Jackson CM;Terrill SJ;Eckel LA;Williams DL
雌激素通过增强对饱足信号的反应来抑制进食。胰高血糖素样肽1（GLP-1）作用于外周和中枢的受体群体，以影响食物摄入。我们推测，调节中枢GLP-1系统是雌激素对摄食影响的机制之一。我们评估了在激素处理后第二天，在黑暗开始前30分钟，以2 μg β-雌二醇-3-苯甲酸酯（EB）或油溶剂的循环方案向双侧卵巢切除（OVX）雌性大鼠的侧脑室给予0、1和10 μg剂量的GLP-1的抗肿瘤作用。与溶媒相比，两种剂量的中枢GLP-1处理均显著抑制了EB处理大鼠的摄食量，而仅10 μg GLP-1剂量在油处理大鼠中有效。为了随访，我们检查了生理剂量的周期性雌二醇治疗是否影响GLP-1诱导的c-Fos在OVX雌性动物的摄食相关脑区。GLP-1显著增加最后区（AP）和孤束核（NTS）中的c-Fos表达，并且下丘脑室旁核（PVN）中的这种效应可能需要雌激素的存在。总之，这些数据表明，调节中枢GLP-1系统可能是雌激素抑制食物摄入的机制之一，并强调PVN是未来研究的关注区域。
Estrogens suppress feeding in part by enhancing the response to satiation signals. Glucagon-like peptide 1 (GLP-1) acts on receptor populations both peripherally and centrally to affect food intake. We hypothesized that modulation of the central GLP-1 system is one of the mechanisms underlying the effects of estrogens on feeding. We assessed the anorexic effect of 0, 1, and 10 μg doses of GLP-1 administered into the lateral ventricle of bilaterally ovariectomized (OVX) female rats on a cyclic regimen of either 2 μg β-estradiol-3-benzoate (EB) or oil vehicle 30 min prior to dark onset on the day following hormone treatment. Central GLP-1 treatment significantly suppressed food intake in EB-treated rats at both doses compared to vehicle, whereas only the 10 μg GLP-1 dose was effective in oil-treated rats. To follow up, we examined whether physiologic-dose cyclic estradiol treatment influences GLP-1-induced c-Fos in feeding-relevant brain areas of OVX females. GLP-1 significantly increased c-Fos expression in the area postrema (AP) and nucleus of the solitary tract (NTS), and the presence of estrogens may be required for this effect in the paraventricular nucleus of the hypothalamus (PVN). Together, these data suggest that modulation of the central GLP-1 system may be one of the mechanisms by which estrogens suppress food intake, and highlight the PVN as a region of interest for future investigation.
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DOI：
10.1523/jneurosci.3262-11.2011
发表时间：
2011-10-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dossat AM;Lilly N;Kay K;Williams DL
通讯作者：
Williams DL
影响因子：
3
作者：
Eckel, LA;Geary, N
通讯作者：
Geary, N
DOI：
10.1152/ajpendo.00413.2013
发表时间：
2013-12-01
影响因子：
5.1
作者：
Mietlicki-Baase, Elizabeth G.;Ortinski, Pavel I.;Hayes, Matthew R.
通讯作者：
Hayes, Matthew R.
影响因子：
3.3
作者：
Larsen, PJ;TangChristensen, M;Orskov, C
通讯作者：
Orskov, C
影响因子：
3.5
作者：
Asarian, L;Geary, N
通讯作者：
Geary, N