3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility.
3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility.
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DOI：
10.1038/s41598-020-74264-w
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发表时间：
2020-10-22
影响因子：
4.6
通讯作者：
Chatzizisis YS
中科院分区：
文献类型：
--
作者：
Wu W;Samant S;de Zwart G;Zhao S;Khan B;Ahmad M;Bologna M;Watanabe Y;Murasato Y;Burzotta F;Brilakis ES;Dangas G;Louvard Y;Stankovic G;Kassab GS;Migliavacca F;Chiastra C;Chatzizisis YS
分叉解剖和疾病负担的三维表示对于更好地理解分叉疾病的解剖复杂性和支架置入术策略的规划至关重要。我们提出了一种基于血管造影的冠状动脉分支三维重建的新方法，血管造影提供了分支的主干，光学相干断层扫描（OCT）提供了血管形状。我们的方法引入了一些技术创新来解决OCT框架错位、OCT框架在隆突处的正确定位、管腔表面重建和分叉管腔的合并。对比对比增强微计算机断层扫描（µCT）作为参考，在n = 5例患者特异性硅胶分叉中测试了该方法的准确性和可重复性。在n = 7个不同解剖复杂性的病变患者分叉中探讨了该方法的可行性和时效性。与微CT参考模型相比，基于oct的重建分岔模型具有非常高的一致性，归一化管腔区域的r2值在0.91和0.98之间，管腔形状和分岔角的平均差异为0.005度和0.004度。同样，我们的方法的可重复性非常高。我们的方法成功地重建了所有患者的分叉，产生了有利的处理时间（平均管腔重建时间< 60分钟）。总的来说，我们的方法是一种易于应用，时间效率高，用户友好的工具，允许准确和可重复的冠状动脉分叉三维重建。我们的技术可用于临床环境，提供有关分叉解剖和斑块负担的信息，从而使分叉支架置入术的计划、教育和决策成为可能。
The three-dimensional (3D) representation of the bifurcation anatomy and disease burden is essential for better understanding of the anatomical complexity of bifurcation disease and planning of stenting strategies. We propose a novel methodology for 3D reconstruction of coronary artery bifurcations based on the integration of angiography, which provides the backbone of the bifurcation, with optical coherence tomography (OCT), which provides the vessel shape. Our methodology introduces several technical novelties to tackle the OCT frame misalignment, correct positioning of the OCT frames at the carina, lumen surface reconstruction, and merging of bifurcation lumens. The accuracy and reproducibility of the methodology were tested in n = 5 patient-specific silicone bifurcations compared to contrast-enhanced micro-computed tomography (µCT), which was used as reference. The feasibility and time-efficiency of the method were explored in n = 7 diseased patient bifurcations of varying anatomical complexity. The OCT-based reconstructed bifurcation models were found to have remarkably high agreement compared to the µCT reference models, yielding r2 values between 0.91 and 0.98 for the normalized lumen areas, and mean differences of 0.005 for lumen shape and 0.004 degrees for bifurcation angles. Likewise, the reproducibility of our methodology was remarkably high. Our methodology successfully reconstructed all the patient bifurcations yielding favorable processing times (average lumen reconstruction time < 60 min). Overall, our method is an easily applicable, time-efficient, and user-friendly tool that allows accurate and reproducible 3D reconstruction of coronary bifurcations. Our technique can be used in the clinical setting to provide information about the bifurcation anatomy and plaque burden, thereby enabling planning, education, and decision making on bifurcation stenting.
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影响因子：
8.3
作者：
Lee, Sang-Wook;Antiga, Luca;Steinman, David A.
通讯作者：
Steinman, David A.
影响因子：
6.2
作者：
Kweon, Jihoon;Kang, Soo-Jin;Park, Seung-Jung
通讯作者：
Park, Seung-Jung
DOI：
10.4244/eijv11sva7
发表时间：
2015-01-01
期刊：
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
影响因子：
--
作者：
Migliavacca, Francesco;Chiastra, Claudio;Dubini, Gabriele
通讯作者：
Dubini, Gabriele
影响因子：
2.4
作者：
van der Giessen, Alina G.;Groen, Harald C.;Gijsen, Frank J. H.
通讯作者：
Gijsen, Frank J. H.
影响因子：
7.5
作者：
Markl, Michael;Wegent, Felix;Harloff, Andreas
通讯作者：
Harloff, Andreas