The presence of pepsin in the lung and its relationship to pathologic gastro-esophageal reflux.
The presence of pepsin in the lung and its relationship to pathologic gastro-esophageal reflux.
复制标题
DOI：
10.1111/j.1365-2982.2011.01826.x
复制
发表时间：
2012-02
影响因子：
3.5
通讯作者：
Nurko S
中科院分区：
文献类型：
--
作者：
Rosen R;Johnston N;Hart K;Khatwa U;Nurko S
胃蛋白酶已被提议作为反流相关肺病的生物标志物。本研究的目的是确定1）肺胃蛋白酶阳性患者中是否存在较高的反流负荷（通过pH-MII测量）和2）胃蛋白酶在通过pH、MII和EGD预测病理性反流中的敏感性。我们招募了年龄在1-21岁之间的慢性咳嗽或哮喘儿童，他们接受了支气管镜检查、食管胃管镜检查（EGD）和多通道腔内阻抗（pH-MII）探头放置。比较胃蛋白酶阳性和阴性患者的反流特征;使用卡方分析比较比例，使用t检验比较平均值。只有非酸反流事件的平均数与胃蛋白酶阳性相关（0.04）。pH-MII和EGD预测胃蛋白酶病理反流的敏感性和特异性分别为57%和65%。胃蛋白酶对pH、MII或EGD预测病理性反流的阳性预测值为50%（11/22），阴性预测值为71%（20/28）。胃蛋白酶阳性患者的平均LLMI显著高于胃蛋白酶阴性患者（81±54 vs. 47±26，p=0.001）。肺胃蛋白酶不能预测食管中的病理性反流，但其与肺部炎症的相关性表明胃蛋白酶可能是反流相关肺部疾病的重要生物标志物。
Pepsin has been proposed as a biomarker of reflux related lung disease. It is the goal of this study to determine 1) if there is a higher reflux burden as measured by pH-MII in patients that are pepsin positive in the lung and 2) the sensitivity of pepsin in predicting pathologic reflux by pH, MII and EGD. We recruited children between the ages of 1–21 with chronic cough or asthma undergoing bronchoscopy, esophagogastroduodenoscopy (EGD), and multichannel intraluminal impedance (pH-MII) probe placement. The reflux profiles were compared between those patients that were pepsin positive and negative; proportions were compared using Chi square analyses and means were compared using t testing. Only the mean number of non-acid reflux events was associated with pepsin positivity (0.04). The sensitivity and specificity of pepsin in predicting pathologic reflux by pH-MII or EGD was 57% and 65% respectively. The positive predictive value of pepsin in predicting pathologic reflux by pH, MII or EGD was 50% (11/22) and the negative predictive value was 71% (20/28). There was a significantly higher mean LLMI in patients that were pepsin positive compared to pepsin negative patients (81±54 vs. 47±26, p=0.001). Lung pepsin cannot predict pathologic reflux in the esophagus but its correlation with lung inflammation suggests that pepsin may be a important biomarker for reflux-related lung disease.
登录
查看更多内容
影响因子：
24.3
作者：
Kazachkov, MY;Muhlebach, MS;Noah, TL
通讯作者：
Noah, TL
影响因子：
3.8
作者：
Gopalareddy, Vani;He, Zhaoping;Mehta, Devendra I.
通讯作者：
Mehta, Devendra I.
影响因子：
3.1
作者：
COLOMBO, JL;HALLBERG, TK
通讯作者：
HALLBERG, TK
DOI：
10.1097/01.mpg.0000232015.56155.03
发表时间：
2006-09-01
影响因子：
2.9
作者：
Farhath, Sabeena;Aghai, Zubair H.;Mehta, Devendra I.
通讯作者：
Mehta, Devendra I.
DOI：
10.1152/ajplung.00310.2003
发表时间：
2004-02-01
影响因子：
4.9
作者：
Foster, C;Aktar, A;Guttentag, S
通讯作者：
Guttentag, S