Association between High Pericoronary Adipose Tissue Computed Tomography Attenuation and Impaired Flow-Mediated Dilation of the Brachial Artery.
Association between High Pericoronary Adipose Tissue Computed Tomography Attenuation and Impaired Flow-Mediated Dilation of the Brachial Artery.
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DOI：
10.5551/jat.63580
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发表时间：
2023-04-01
影响因子：
4.4
通讯作者：
Ito H
中科院分区：
文献类型：
--
作者：
Ichikawa K;Miyoshi T;Ohno Y;Osawa K;Nakashima M;Nishihara T;Miki T;Toda H;Yoshida M;Ito H
目的：冠状动脉计算机断层扫描血管造影（CTA）上的冠状动脉周围脂肪组织（PCAT）衰减是冠状动脉周围炎症的非侵入性生物标志物，与心脏死亡率相关。我们的目的是研究PCAT衰减和内皮功能障碍之间的关联使用流量介导的扩张（FMD）评估。 方法：对119例同时行冠状动脉CTA和FMD测量的门诊患者进行检查。在冠状动脉CTA上评估所有三个主要冠状动脉近端40 mm节段的PCAT衰减值。使用FMD评估内皮功能。将患者分为内皮功能障碍组（FMD <4%，n = 44）和无内皮功能障碍组（FMD ≥ 4%，n = 75）。 结果如下：在所有三支冠状动脉中，内皮功能障碍患者的PCAT衰减显著高于无内皮功能障碍患者。多因素Logistic回归分析显示，右冠状动脉（OR = 1.543，95%CI = 1.004-2.369，p = 0.048）和左前降支（OR = 1.525，95%CI = 1.004-2.369，p = 0.049）的PCAT衰减是内皮功能障碍的独立预测因子。对有不良CTA结果（显著狭窄和/或高危斑块）和冠状动脉钙化评分> 100的患者进行亚组分析，结果显示所有三支冠状动脉的高PCAT衰减是内皮功能障碍的重要预测因素。 结论：高PCAT衰减与FMD评估的疑似冠心病患者的内皮功能障碍显著相关。我们的研究结果表明，内皮功能障碍是冠状动脉周围炎症与心脏死亡率相关的病理生理机制之一。
Aims: Pericoronary adipose tissue (PCAT) attenuation on coronary computed tomography angiography (CTA) is a noninvasive biomarker for pericoronary inflammation and is associated with cardiac mortality. We aimed to investigate the association between PCAT attenuation and endothelial dysfunction assessed using flow-mediated dilation (FMD). Methods: A total of 119 outpatients who underwent both coronary CTA and FMD measurements were examined. PCAT attenuation values were assessed at the proximal 40-mm segments of all three major coronary arteries on coronary CTA. Endothelial function was assessed using FMD. Patients were then classified into two groups: those with endothelial dysfunction (FMD ＜4%,n=44) and those without endothelial dysfunction (FMD ≥ 4%,n=75). Results: In all three coronary arteries, PCAT attenuation was significantly higher in patients with endothelial dysfunction than in those without endothelial dysfunction. Multivariate logistic regression analysis revealed that PCAT attenuation in the right coronary artery (odds ratio [OR]=1.543; 95% confidence interval [CI]=1.004–2.369,p=0.048) and left anterior descending artery (OR=1.525, 95% CI=1.004–2.369,p=0.049) was an independent predictor of endothelial dysfunction. Subgroup analysis of patients with adverse CTA findings (significant stenosis and/or high-risk plaque) and those with coronary artery calcium score ＞100 showed that high PCAT attenuation in all three coronary arteries was a significant predictor of endothelial dysfunction. Conclusion: High PCAT attenuation was significantly associated with FMD-assessed endothelial dysfunction in patients with suspected coronary artery disease. Our results suggest that endothelial dysfunction is one of the pathophysiological mechanisms linking pericoronary inflammation to cardiac mortality.
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影响因子：
9.3
作者：
Ichikawa K;Miyoshi T;Osawa K;Miki T;Toda H;Ejiri K;Yoshida M;Nanba Y;Yoshida M;Nakamura K;Morita H;Ito H
通讯作者：
Ito H
影响因子：
9.3
作者：
Ohno Y;Miyoshi T;Noda Y;Oe H;Toh N;Nakamura K;Kohno K;Morita H;Ito H
通讯作者：
Ito H
影响因子：
7.5
作者：
Mehta, Anurag;Pandey, Ambarish;Joshi, Parag H.
通讯作者：
Joshi, Parag H.
DOI：
10.1016/s0735-1097(03)00927-6
发表时间：
2003-09-17
影响因子：
24
作者：
Chan, SY;Mancini, GBJ;Ignaszewski, A
通讯作者：
Ignaszewski, A
影响因子：
5.4
作者：
Hoshino, Masahiro;Yang, Seokhun;Kakuta, Tsunekazu
通讯作者：
Kakuta, Tsunekazu