Bezafibrate improves postprandial hypertriglyceridemia and associated endothelial dysfunction in patients with metabolic syndrome: a randomized crossover study.
Bezafibrate improves postprandial hypertriglyceridemia and associated endothelial dysfunction in patients with metabolic syndrome: a randomized crossover study.
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DOI：
10.1186/1475-2840-13-71
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发表时间：
2014-04-05
影响因子：
9.3
通讯作者：
Ito H
中科院分区：
文献类型：
--
作者：
Ohno Y;Miyoshi T;Noda Y;Oe H;Toh N;Nakamura K;Kohno K;Morita H;Ito H
餐后富含甘油三酯的脂蛋白升高会损害内皮功能，从而引发动脉粥样硬化。我们研究了苯扎贝特对代谢综合征患者餐后内皮功能障碍和血脂的影响。在一项随机交叉研究中，10名代谢综合征患者接受了400 mg/天的苯扎贝特治疗或4周不治疗。在禁食期间和食用标准零食后，评估了肱动脉血流介导的扩张(FMD)和血脂谱。用高效液相色谱法测定血清甘油三酯和脂蛋白各组份的胆固醇含量。苯扎贝特组和对照组的餐后FMD均显著下降，并在饼干试验后4小时降至最低值，但苯扎贝特组餐后FMD从基线到最小的相对变化显著小于对照组(-29.0 ± 5.9vs.-42.9 ± 6.2%，p = 0.04)。苯扎贝特显著抑制餐后甘油三酯(544 ± 65vs.1158 ± 283 mg·h/dl，p = 0.02)和残余脂蛋白胆固醇(AUC：27.9 ± 3.5vs.72.3 ± 14.1mg.h/dl，p <； 0.01)的餐后升高。高效液相色谱分析显示，苯扎贝特组乳糜管和极低密度脂蛋白组餐后甘油三酯的含量显著低于对照组(p <； 0.05)。苯扎贝特显著降低代谢综合征患者餐后内皮细胞功能障碍和外源性和内源性甘油三酯的升高，提示苯扎贝特可能对这些患者具有血管保护作用。唯一标识：UMIN000012557
Postprandial elevation of triglyceride-rich lipoproteins impairs endothelial function, which can initiate atherosclerosis. We investigated the effects of bezafibrate on postprandial endothelial dysfunction and lipid profiles in patients with metabolic syndrome. Ten patients with metabolic syndrome were treated with 400 mg/day bezafibrate or untreated for 4 weeks in a randomized crossover study. Brachial artery flow-mediated dilation (FMD) and lipid profiles were assessed during fasting and after consumption of a standardized snack. Serum triglyceride and cholesterol contents of lipoprotein fractions were analyzed by high-performance liquid chromatography. Postprandial FMD decreased significantly and reached its lowest value 4 h after the cookie test in both the bezafibrate and control groups, but the relative change in FMD from baseline to minimum in the bezafibrate group was significantly smaller than that in the control group (-29.0 ± 5.9 vs. -42.9 ± 6.2 %, p = 0.04). Bezafibrate significantly suppressed postprandial elevation of triglyceride (incremental area under the curve (AUC): 544 ± 65 vs. 1158 ± 283 mg h/dl, p = 0.02) and remnant lipoprotein cholesterol (incremental AUC: 27.9 ± 3.5 vs. 72.3 ± 14.1 mg h/dl, p < 0.01). High-performance liquid chromatography analysis revealed that postprandial triglyceride content of the chylomicron and very low-density lipoprotein fractions was significantly lower in the bezafibrate group than in the control group (p < 0.05). Bezafibrate significantly decreased postprandial endothelial dysfunction, and elevations of both exogenous and endogenous triglycerides in patients with metabolic syndrome, suggesting that bezafibrate may have vascular protective effects in these patients. Unique Identifiers: UMIN000012557
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影响因子：
--
作者：
Tenenbaum, A;Motro, M;Behar, S
通讯作者：
Behar, S
影响因子：
2.8
作者：
Goldenberg, Ilan;Benderly, Michal;Behar, Shlomo
通讯作者：
Behar, Shlomo
影响因子：
39.3
作者：
Tenenbaum, A;Motro, M;Behar, S
通讯作者：
Behar, S
影响因子：
16.2
作者：
Rosenson, Robert S.;Wolff, David A.;Rademaker, Alfred W.
通讯作者：
Rademaker, Alfred W.
影响因子：
37.8
作者：
Evans, M;Anderson, RA;Rees, A
通讯作者：
Rees, A