Coronary intravascular lithotripsy for coronary artery calcifications- systematic review of cases.

Coronary intravascular lithotripsy for coronary artery calcifications- systematic review of cases.
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冠状动脉钙化的冠状动脉血管内碎石术-病例的系统回顾。

DOI:
10.1080/20009666.2021.1883219
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发表时间:
2021-03-23
影响因子:
1
通讯作者:
Alraies MC
Alraies MC
中科院分区:
其他
文献类型:
--
作者:
Sattar Y;Ullah W;Virk HUH;Doshi R;Rauf H;Desai H;Panchal A;Nasir M;Almas T;Ullah I;Pacha HM;Zaher N;Alraies MC

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背景:冠状动脉钙化(CAC)是一种钙化在动脉壁内膜和中层的病理性沉积。治疗CAC有太多的治疗性钙化技术,包括眼眶或旋转动脉粥样硬化切除术、准分子激光、切割和记分球囊,这些技术与并发症发生率飙升和疗效低下相关。为此,2016年,美国食品和药物管理局(FDA)提出,可以采用冲击波血管内碎石(S-IVL)技术,并发症最小。方法:利用PubMed、Embase和Cochrane中央对照试验登记处的在线数据,对因钙化冠状动脉疾病而行碎石术的病例进行回顾性分析。现有的搜索结果被下载到Endnote图书馆,并分两个阶段进行分析。结果:在病例报道和系列报道的24名参与者中,大多数是男性。因左主干狭窄、左前降支狭窄、左回旋支狭窄或斜支狭窄而行IVL的患者病死率无显著差异。6例有合并症且接受3个以上体外循环的患者病死率较高(OR37,95%CLA1.54~886.04,P0.02)。24例中有2例(8.33%)发生血管夹层等并发症(OR 3.4,95%CI 17.87~64.68,P0.4)。结论:血管内冲击波碎石术可用于钙化性病变的血管腔内扩张,并可用于药物洗脱支架的置入。IVL置入DES的成功率为100%,并发症发生率低。
Background: Coronary artery calcification (CAC) is a pathological deposition of calcium in the intimal and medial layer of the arterial wall. A plethora of therapeutic calcium debulking techniques is available for the treatment of CAC, including orbital or rotational atherectomy, excimer lasers, cutting, and scoring balloons, which are associated with a soaring rate of complication and low efficacy. To this end, in 2016, the Food and Drug Administration (FDA) posited that shockwave intravascular lithotripsy (S-IVL) technique can be employed with minimal complication. Methods: A retrospective review of cases received lithotripsy for calcified coronary artery disease was performed by using online data from PubMed, Embase, and the Cochrane Central Register of Controlled Trials. The available search results were downloaded into an Endnote library and analyzed into two phases. Results: Out of 24 participants from case reports and series, Majority were found to be Male. There was no significant difference found in the mortality of patients undergoing IVL for the stenosis of the left main stem, left anterior descending, left circumflex artery, or diagonal branch. The mortality was found to be high among 6 patients with prior comorbidities and underwent more than 3 cycles of IVL (OR 37,95% Cl 1.54–886.04, P 0.02). Out of 24 patients, 2 (8.33%) patients developed complications such as vessel dissection (OR 3.4, 95% Cl 17.87–64.68, P 0.4). Conclusion: Shockwave intravascular lithotripsy (S-IVL) may be used in cases of the calcified disease to gain vessel lumen in order to deploy drug-eluting stents with PCI. The success of the DES implantation of IVL can be 100% with a minimal complication rate.
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