Unobtrusive assessment of activity patterns associated with mild cognitive impairment.
Unobtrusive assessment of activity patterns associated with mild cognitive impairment.
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DOI：
10.1016/j.jalz.2008.07.004
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发表时间：
2008-11
影响因子：
14
通讯作者：
Kaye, Jeffrey A.
中科院分区：
文献类型：
--
作者：
Hayes, Tamara L.;Abendroth, Francena;Adami, Andre;Pavel, Misha;Zitzelberger, Tracy A.;Kaye, Jeffrey A.
关键词：
及时发现早期认知障碍是困难的。在临床上采取的措施反映了一个单一的快照的性能，可能会混淆的增加变异性典型的老化和疾病。我们评估了使用连续的，长期的和不显眼的家庭监测，以评估健康和认知功能受损的老年人的神经功能。14名65岁及以上独立生活在社区的老年人在家中使用不显眼的传感器系统进行监测。获得了步行速度和家中活动量的测量结果。使用小波分析来检查多个时间尺度下的活性的方差。在长达418天（平均315 ± 82天）的时间内收集了超过108，000人小时的连续活动数据。MCI组中位步行速度的变异系数（0.147 ± 0.074）是健康组（0.079 ± 0.027; t11 = 2.266，p<0.03）的两倍。此外，MCI组的24小时小波方差更大（MCI：4.07 ± 0.14，健康老年人：3.79± 0.23; F = 7.58，p=<0.008），表明MCI组受试者的日常活动模式比认知健康对照组更易变。结果不仅证明了这些方法的可行性，但也表明这种新的方法明显的潜在优势。与临床环境中的常规情景测试相比，这种方法可以提供检测最早转变为MCI的改进手段。
Timely detection of early cognitive impairment is difficult. Measures taken in the clinic reflect a single snapshot of performance that may be confounded by the increased variability typical in aging and disease. We evaluated the use of continuous, long-term and unobtrusive in-home monitoring to assess neurological function in healthy and cognitively impaired elders. Fourteen older adults 65 years and older living independently in the community were monitored in their homes using an unobtrusive sensor system. Measures of walking speed and amount of activity in the home were obtained. Wavelet analysis was used to examine variance in activity at multiple timescales. More than 108,000 person-hours of continuous activity data were collected over periods as long as 418 days (mean 315 ± 82 days). The coefficient of variation in the median walking speed was twice as high in the MCI group (0.147 ± 0.074) as compared to the healthy group (0.079 ± 0.027; t11 = 2.266, p<0.03). Furthermore, the 24-hour wavelet variance was greater in the MCI group (MCI: 4.07 ± 0.14, Healthy elderly: 3.79± 0.23; F = 7.58, p=<0.008), indicating that the day-to-day pattern of activity of subjects in the MCI group was more variable than that of the cognitively healthy controls. The results not only demonstrate the feasibility of these methods, but also suggest clear potential advantages to this new methodology. This approach may provide an improved means of detecting the earliest transition to MCI compared to conventional episodic testing in a clinic environment.
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影响因子：
39.2
作者：
CALLAHAN, CM;HENDRIE, HC;TIERNEY, WM
通讯作者：
TIERNEY, WM
影响因子：
7
作者：
Quayhagen, MP;Quayhagen, M;Bower, D
通讯作者：
Bower, D
DOI：
10.1016/s0003-9993(96)90258-0
发表时间：
1996-08-01
影响因子：
4.3
作者：
Kochersberger, G;McConnell, E;Pieper, C
通讯作者：
Pieper, C
DOI：
10.1093/geronj/24.2.169
发表时间：
1969-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
MURRAY, MP;KORY, RC;CLARKSON, BH
通讯作者：
CLARKSON, BH
影响因子：
2.4
作者：
Gwyther, LP
通讯作者：
Gwyther, LP