Fuels and pathways as designed systems for support of muscle work.
Fuels and pathways as designed systems for support of muscle work.
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燃料和路径作为支持肌肉工作的设计系统。
DOI：
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发表时间：
1985
影响因子：
2.8
通讯作者：
P. W. Hochachka
中科院分区：
文献类型：
--
作者：
P. W. Hochachka
所有动物的肌肉都依赖于四种潜在的能量来源：三磷酸腺苷水解酶、磷酸原水解酶、发酵或氧化代谢。尽管不同生物体中不同燃料的相对贡献差异很大，但没有一个生物体简单地依赖于储存的ATP。因此，肌肉工作需要在ATP的利用率和形成之间取得平衡，ATP是由剩余的三种燃料和代谢途径中的一种提供的。有用的内源燃料必须在高水平下储存，并在[ATP]扰动最小的情况下快速动员，并且最终产物对pH、电荷或渗透平衡的影响最小。除了表现出这些特性外，良好的外源燃料必须能够在库位和肌肉之间高速转移；外源燃料的实际通量取决于各自的ATP产量，对于最能放大每摩尔底物氧化的ATP产量的燃料来说，外源燃料的实际通量最低。底物通量速率必须与O2通量速率和内源底物动员速率相匹配，以便在正确的时间激活正确的能量产生途径。在各种控制可能性中，对ADP(可能还有PI)的有效竞争目前似乎是确保有氧和无氧ATP产生途径整合的主导策略。
Muscle in all animals relies upon four potential sources of energy: ATP hydrolysis, phosphagen hydrolysis, fermentations or oxidative metabolism. Although the relative contributions of different fuels varies greatly in different organisms, in none is there a simple reliance on stored ATP. Muscle work therefore requires a balance between rates of utilization and formation of ATP, a provision supplied by one of the three remaining fuels and metabolic pathways. Useful endogenous fuels must be storable at high level, and rapidly mobilizable with minimal perturbation of [ATP] and with minimal end-product effects on pH, charge or osmotic balance. In addition to displaying these properties, good exogenous fuels must be transferable at high rates between depot sites and muscle; actual flux rates of exogenous fuels depend upon respective ATP yields and are lowest for fuels which most amplify the yield of ATP per mol substrate oxidized. Substrate flux rates must be matched with O2 flux rates and with rates of endogenous substrate mobilization in order that the right energy-yielding pathways are activated at the right times. Of various control possibilities, an effective competition for ADP (and possibly Pi) seems at this time to be the dominant strategy for assuring integration of aerobic and anaerobic ATP-yielding pathways.
DOI：
10.1016/s0021-9258(18)34936-6
发表时间：
1982-03
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
W E Jacobus;R W Moreadith;K M Vandegaer
通讯作者：
W E Jacobus;R W Moreadith;K M Vandegaer
影响因子：
3.9
作者：
DAVIES, KJA;PACKER, L;BROOKS, GA
通讯作者：
BROOKS, GA