Biological soliton in multicellular movement.

Biological soliton in multicellular movement.
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DOI:
10.1038/srep02272
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发表时间:
2013
期刊:
影响因子:
4.6
通讯作者:
Ishida, Shuji
Ishida, Shuji
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Kuwayama, Hidekazu;Ishida, Shuji

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人们在各种物理现象中都观察到了孤子。在这里,我们表明,孤子的独特特征存在于细胞粘菌盘基网柄菌非趋化突变体的大量细胞运动中。在饥饿期间,盘状 D. discoideum 形成多细胞结构,分化为孢子或茎细胞,并最终分化为子实体。非趋化突变细胞不形成多细胞结构;然而,它们确实以脉动孤子结构(SLS)的形式经历大量细胞运动。我们还发现 SLS 诱导是由粘附细胞-细胞相互作用介导的。这些观察结果为多细胞运动中生物孤子的机制提供了新的见解。
Solitons have been observed in various physical phenomena. Here, we show that the distinct characteristics of solitons are present in the mass cell movement of non-chemotactic mutants of the cellular slime mould Dictyostelium discoideum. During starvation, D. discoideum forms multicellular structures that differentiate into spore or stalk cells and, eventually, a fruiting body. Non-chemotactic mutant cells do not form multicellular structures; however, they do undergo mass cell movement in the form of a pulsatile soliton-like structure (SLS). We also found that SLS induction is mediated by adhesive cell-cell interactions. These observations provide novel insights into the mechanisms of biological solitons in multicellular movement.
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