Kinetics of the phenotype and function of murine peritoneal macrophages following acute inflammation.

Kinetics of the phenotype and function of murine peritoneal macrophages following acute inflammation.
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急性炎症后小鼠腹腔巨噬细胞表型和功能的动力学。

DOI:
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发表时间:
2004-02
影响因子:
24.1
通讯作者:
Zou JP*.
Zou JP*.
中科院分区:
医学1区
文献类型:
--
作者:
Wu QL;Feng HY;Yang YF;Liu J;Zhou WL;He PL;Zhou R;Li XY;Zou JP*.

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本研究旨在更好地了解限制巨噬细胞活化和活化巨噬细胞群体的过程和潜在机制。在从Balb/c小鼠中回收的小鼠腹腔巨噬细胞中进行细胞因子产生的综合动力学,在腹腔内注射巯基乙酸盐(TG)的过程中的不同时间。流式细胞仪检测巨噬细胞表面分子MHC-I、MHC-II、B7-1和B7-2的表达。我们的研究结果表明,在炎症过程中,活化的巨噬细胞的数量和巨噬细胞的活化(包括细胞因子的产生和细胞表面功能分子的表达)受到严格的控制。这是维持宿主体内平衡的重要机制之一。
This study was undertaken to have a better understanding for the process and the underlying mechanisms to limit macrophage activation and population of activated macrophages. A comprehensive kinetics of cytokine production was performed in murine peritoneal macrophages recovered from Balb/c mice at various time during the course of an intraperitoneal injection with thioglycollate (TG). The expression of cell surface molecules such as MHC-I, MHC-II, B7-1 and B7-2 of these macrophages were also determined by flow cytometry. The present findings of our research suggested that the population of activated macrophages and the activation of macrophages (including cytokines production and expression of cell surface functional molecules) were strictly controlled during inflammation process. This is one of the important mechanisms to retain the host homeostasis.
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影响因子: 4.4
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