The association of biomarkers of iron status with mortality in US adults.
The association of biomarkers of iron status with mortality in US adults.
复制标题
DOI：
10.1016/j.numecd.2010.11.011
复制
发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Guallar E
中科院分区：
文献类型：
--
作者：
Menke A;Muntner P;Fernández-Real JM;Guallar E
在普通人群中，铁生物标志物升高与糖尿病和其他心脏代谢异常有关。目前尚不清楚它们是否与全因死亡率或特定原因死亡率的风险增加有关。当前分析的目的是评估美国普通成年人中铁蛋白和转铁蛋白饱和度水平与全因死亡率、心血管死亡率和癌症死亡率的关系。一项前瞻性队列研究对参加第三次全国健康和营养检查调查（NHANES III）的12258名成年人进行了研究，这是一个具有全国代表性的美国人口样本。研究参与者于1988年至1994年招募，随访至2006年12月31日，调查全因、心血管疾病和癌症死亡率。多变量校正的全因死亡率比较铁蛋白和转铁蛋白饱和度第4和第2四分位数的风险比（95%可信区间）分别为1.09 （0.82-1.44；p趋势跨四分位数=0.92）和1.08 (0.82-1.43；p趋势跨四分位数=0.62)，绝经前妇女分别为1.43 （0.63-3.23；p趋势跨四分位数=0.31）和1.48 （0.70-3.11；p趋势跨四分位数=0.60）和1.03 (0.79-1.34；绝经后妇女的p趋势跨四分位数=0.95)和1.17 （0.92-1.49；p趋势跨四分位数=0.63）。铁蛋白和转铁蛋白饱和度的四分位数也显示铁状态和死亡率之间的生物标志物没有关联。在一个具有全国代表性的美国成年人大样本中，在正常铁代谢范围内，铁蛋白和转铁蛋白饱和度与没有服用铁补充剂和没有心血管疾病或癌症基线史的人的死亡风险无关。
Elevated iron biomarkers are associated with diabetes and other cardiometabolic abnormalities in the general population. It is unclear whether they are associated with an increased risk of all cause or cause-specific mortality. The purpose of the current analysis was to evaluate the association of ferritin and transferrin saturation levels with all-cause, cardiovascular, and cancer mortality in the general US adult population. A prospective cohort study was conducted with 12,258 adults participating in the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of the US population. Study participants were recruited in 1988 to 1994 and followed through December 31, 2006 for all-cause, cardiovascular disease, and cancer mortality. The multivariable-adjusted hazard ratios (95% confidence interval) for all-cause mortality comparing the fourth versus the second quartiles of ferritin and transferrin saturation were 1.09 (0.82–1.44; p-trend across quartiles=0.92) and 1.08 (0.82–1.43; p-trend across quartiles=0.62), respectively, for men, 1.43 (0.63–3.23; p-trend across quartiles=0.31) and 1.48 (0.70–3.11; p-trend across quartiles=0.60), respectively, for premenopausal women, and 1.03 (0.79–1.34; p-trend across quartiles=0.95) and 1.17 (0.92–1.49; p-trend across quartiles=0.63), respectively, for postmenopausal women. Quartile of ferritin and transferrin saturation also showed no association between biomarkers of iron status and mortality. In a large nationally representative sample of US adults, within the spectrum of normal iron metabolism, ferritin and transferrin saturation were not associated with risk of mortality among people who were not taking iron supplements and did not have a baseline history of cardiovascular disease or cancer.
登录
查看更多内容
影响因子：
--
作者：
Zakai, NA;Katz, R;Cushman, M
通讯作者：
Cushman, M
影响因子：
7.7
作者：
Fernández-Real, JM;Peñarroja, G;Ricart, W
通讯作者：
Ricart, W
影响因子：
2.1
作者：
Waalen, J;Nordestgaard, BG;Beutler, E
通讯作者：
Beutler, E
影响因子：
16.2
作者：
Jehn, M;Clark, JM;Guallar, E
通讯作者：
Guallar, E
影响因子：
39.2
作者：
Levey, Andrew S.;Coresh, Josef;Van Lente, Frederick
通讯作者：
Van Lente, Frederick