Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes.
Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes.
复制标题
成人心室肌细胞之间间隙连接的一些电学和药理学特性。
DOI:
10.1152/ajpcell.1985.249.5.c447
复制
发表时间:
1985
期刊:
影响因子:
--
通讯作者:
Bennett,MV
中科院分区:
文献类型:
--
作者:
White,RL;Spray,DC;CamposdeCarvalho,AC;Wittenberg,BA;Bennett,MV
Ventricular myocytes were isolated from adult rat hearts using the technique of Wittenberg and Robinson (Cell Tissue Res. 216: 231-251, 1981). These cells exhibited morphology, input resistance, time constant, and excitability expected for cells in intact cardiac tissue. Pairs of these cells were electronically coupled, and junctional conductance was unaffected by transjunctional potential or hyperpolarization of both cells. Brief exposure of cell pairs to medium equilibrated with 100% CO2 or containing 0.1 mM octanol quickly and reversibly decreased junctional conductance. We conclude that gap junctions between pairs of ventricular myocytes possess physiological properties like those of junctions in many other tissues. This preparation will be useful in evaluating drug action on junctional communication in heart.
登录
查看更多内容
DOI:
--
发表时间:
1966
期刊:
Journal of Physiology
影响因子:
--
作者:
S. Weidmann;A. Hodgkin
通讯作者:
A. Hodgkin
影响因子:
18.2
作者:
Page,E;Shibata,Y
通讯作者:
Shibata,Y
DOI:
--
发表时间:
1980
期刊:
The Japanese Journal of Physiology
影响因子:
--
作者:
H. Nishiye;H. Mashima;A. Ishida
通讯作者:
A. Ishida
DOI:
--
发表时间:
--
期刊:
影响因子:
--
作者:
W. C. De Mello
通讯作者:
W. C. De Mello
DOI:
10.1073/pnas.79.2.441
发表时间:
1982-01-01
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子:
--
作者:
SPRAY, DC;STERN, JH;BENNETT, MVL
通讯作者:
BENNETT, MVL