Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis.
Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis.
复制标题
盐霉素是一种多层离子抗生素，抑制了糖化。
DOI：
10.1016/j.bbrc.2012.10.080
复制
发表时间：
2012-11-30
影响因子：
3.1
通讯作者：
Chin, Khew-Voon
中科院分区：
文献类型：
--
作者：
Szkudlarek-Mikho, Maria;Saunders, Rudel A.;Yap, Sook Fan;Ngeow, Yun Fong;Chin, Khew-Voon
聚醚离子型抗生素包括莫能菌素、盐碱霉素和那拉西素，广泛应用于兽药和食品添加剂以及畜牧业（包括家禽养殖）中的生长促进剂。然而，它们对人类健康的影响尚不完全清楚。近年来的研究表明，盐碱霉素是一种肿瘤干细胞抑制剂。由于家禽消费在过去三十年中急剧上升，我们想知道食用含有促进生长的抗生素的肉类是否会对脂肪细胞产生影响。我们在本报告中发现，离子性抗生素抑制前脂肪细胞向脂肪细胞的分化。分化的阻断不是由于诱导细胞凋亡，也不是由于抑制细胞增殖。此外，盐碱霉素还能抑制CCAAT/增强子结合蛋白和过氧化物酶体增殖体激活受体γ的转录活性。这些结果表明，离子型抗生素可作为新型抗肥胖药物和脂肪生物学研究的药理学探针。此外，盐碱霉素的药理作用可能是其在癌症治疗中对脂肪组织和其他易感靶细胞毒性的先兆。
The polyether ionophoric antibiotics including monensin, salinomycin, and narasin, are widely used in veterinary medicine and as food additives and growth promoters in animal husbandry including poultry farming. Their effects on human health, however, are not fully understood. Recent studies showed that salinomycin is a cancer stem cell inhibitor. Since poultry consumption has risen sharply in the last three decades, we asked whether the consumption of meat tainted with growth promoting antibiotics might have effects on adipose cells. We showed in this report that the ionophoric antibiotics inhibit the differentiation of preadipocytes into adipocytes. The block of differentiation is not due to the induction of apoptosis nor the inhibition of cell proliferation. In addition, salinomycin also suppresses the transcriptional activity of the CCAAT/enhancer binding proteins and the peroxisome proliferator-activated receptor γ. These results suggest that the ionophoric antibiotics can be exploited as novel anti-obesity therapeutics and as pharmacological probes for the study of adipose biology. Further, the pharmacological effects of salinomycin could be a harbinger of its toxicity on the adipose tissue and other susceptible target cells in cancer therapy.
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DOI：
10.1038/oby.2005.204
发表时间：
2005-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Kawakami, K;Onaka, T;Ikeda, K
通讯作者：
Ikeda, K
影响因子：
3.8
作者：
Simons, PJ;van den Pangaart, PS;Boon, L
通讯作者：
Boon, L
影响因子：
10.4
作者：
Sapkota, Amy R.;Lefferts, Lisa Y.;McKenzie, Shawn;Walker, Polly
通讯作者：
Walker, Polly
影响因子：
64.5
作者：
Gupta PB;Onder TT;Jiang G;Tao K;Kuperwasser C;Weinberg RA;Lander ES
通讯作者：
Lander ES
影响因子：
3
作者：
Huczynski, Adam
通讯作者：
Huczynski, Adam