Dietary Copper and Selenium Intakes and the Risk of Type 2 Diabetes Mellitus: Findings from the China Health and Nutrition Survey.
Dietary Copper and Selenium Intakes and the Risk of Type 2 Diabetes Mellitus: Findings from the China Health and Nutrition Survey.
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膳食铜和硒的摄入量与 2 型糖尿病的风险：中国健康与营养调查的结果
DOI：
10.3390/nu14102055
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发表时间：
2022-05-13
期刊：
影响因子：
5.9
通讯作者：
Meng, Huicui
中科院分区：
文献类型：
--
作者：
Cui, Zhixin;Zhou, Haiyan;Liu, Ke;Wu, Man;Li, Shun;Meng, Shuangli;Meng, Huicui
膳食铜（Cu）和硒（Se）摄入量与2型糖尿病（T2 DM）风险之间的长期关系尚不清楚。我们的目的是研究中国成年人膳食铜和硒摄入量与2型糖尿病风险之间的前瞻性关联。共纳入了来自中国健康与营养调查（1997-2015）的14，711名成年人。通过连续3次24 h回忆和食物称重法评估营养素摄入量。通过经验证的调查问卷和实验室检查确定T2 DM。采用考克斯回归模型进行统计学分析。在147，142人年的随访期间，共诊断出1040例T2 DM病例。在完全校正的模型中，膳食铜或硒摄入量与T2 DM风险无关。膳食硒摄入量显著改变了膳食铜摄入量与T2 DM风险之间的关联，当硒摄入量低于中位数时，膳食铜摄入量与T2 DM风险呈正相关（p-交互作用= 0.0292）。年龄、性别、BMI或地区对相关性没有显著影响。虽然膳食铜或硒摄入量与基线时无心脏代谢疾病和癌症的中国成年人的T2 DM风险没有独立相关性，但膳食铜和硒摄入量对T2 DM风险有显著的交互作用。
The long-term associations between dietary copper (Cu) and selenium (Se) intakes and type 2 diabetes mellitus (T2DM) risk are unclear. We aimed to examine the prospective associations between dietary Cu and Se intakes and T2DM risk in Chinese adults. A total of 14,711 adults from the China Health and Nutrition Survey (1997–2015) were included. Nutrient intakes were assessed by 3 consecutive 24 h recalls and food-weighing methods. T2DM was identified by a validated questionnaire and laboratory examination. Cox regression models were used for statistical analysis. A total of 1040 T2DM cases were diagnosed during 147,142 person-years of follow-up. In fully adjusted models, dietary Cu or Se intake was not associated with T2DM risk. Dietary Se intake significantly modified the association between dietary Cu intake and T2DM risk, and dietary Cu intake was positively associated with T2DM risk when Se intake was lower than the median (p-interaction = 0.0292). There were no significant effect modifications on the associations by age, sex, BMI, or region. Although dietary Cu or Se intake was not independently associated with T2DM risk in Chinese adults free from cardiometabolic diseases and cancer at the baseline, there was a significant interaction between dietary Cu and Se intakes on T2DM risk.
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影响因子：
16.2
作者：
Li Y;Wang DD;Ley SH;Vasanti M;Howard AG;He Y;Hu FB
通讯作者：
Hu FB
DOI：
10.3390/ijerph16071290
发表时间：
2019-04-01
影响因子：
--
作者：
Hu, Yichun;Li, Min;Yang, Xiaoguang
通讯作者：
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影响因子：
6
作者：
Aharon-Hananel G;Romero-Afrima L;Saada A;Mantzur C;Raz I;Weksler-Zangen S
通讯作者：
Weksler-Zangen S
影响因子：
7.1
作者：
Pan, An;Sun, Qi;Hu, Frank B.
通讯作者：
Hu, Frank B.
影响因子：
4.6
作者：
Horn, Darryl;Barrientos, Antoni
通讯作者：
Barrientos, Antoni