Incidence of Neonatal Abstinence Syndrome Epidemic and Associated Predictors in Nevada: A Statewide Audit, 2016-2018.
Incidence of Neonatal Abstinence Syndrome Epidemic and Associated Predictors in Nevada: A Statewide Audit, 2016-2018.
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DOI：
10.3390/ijerph18010232
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发表时间：
2020-12-30
影响因子：
--
通讯作者：
Buttner MP
中科院分区：
文献类型：
--
作者：
Batra K;Cruz P;Cross CL;Bhandari N;Abdulla F;Pharr JR;Buttner MP
新生儿戒断综合征（NAS）是一种出生后戒断综合征的母亲所生的药物依赖性疾病。NAS在全国范围内构成了重大的公共卫生挑战，从2000年到2016年，发病率增加了六倍（每1000名住院分娩/年1.2至6.7）。除了国家数据外，在州一级量化NAS以确定预防目标领域也至关重要。本研究的目的是确定全州范围内的负担，包括2016-2018年期间内华达州NAS的县和区域分布，并调查与NAS相关的潜在因素。本研究利用医院管理数据，共检查了100，845例住院儿科出院病例，以确定NAS病例。统计分析包括估计每1000例住院分娩的粗发病率和多水平logistic回归模型。2016年至2018年，内华达州的NAS发病率从8.6/1000例住院分娩略微下降至7.7/1000例住院分娩，但总体发病率为8/1000例，远高于2013年报告的早期估计值（4.8/1000例住院分娩）。白色新生儿（12，95%CI 11.0，13.0）和医疗补助登记者（13.2，95%CI 11.0，15.0）的发病率不成比例地更高。内华达州南部的发病率最高，每1000名住院分娩中有8.2人。近75%的NAS病例是克拉克县的居民。NAS的发病率与内华达州不断增长的阿片类药物处方率平行，并强调需要采用阿片类药物控制处方实践来对抗这种药物流行病。这些发现可能有助于设计和评估为打击阿片类药物流行而引入的国家和系统级干预措施。
Neonatal abstinence syndrome (NAS) is a postnatal withdrawal syndrome among neonates born to mothers with drug dependence disorders. NAS poses a significant public health challenge nationally, with a six-fold increase in incidence (1.2 to 6.7 per 1000 hospital births/year) from 2000–2016. Besides national data, it is critical to quantify NAS at the state-level to identify target areas for prevention. The objectives of this study were to ascertain statewide burden, including county and regional distribution of NAS in Nevada during 2016–2018, and to investigate potential factors associated with NAS. This study utilized hospital administrative data, and a total of 100,845 inpatient pediatric discharges were examined to identify NAS cases. Statistical analyses included estimation of crude incidence rates per 1000 hospital births and multilevel logistic regression modeling. NAS incidence in Nevada decreased slightly from 8.6 to 7.7 per 1000 hospital births between 2016 and 2018, but the overall incidence of 8 was substantially higher than earlier estimates (4.8/1000 hospital births) reported for 2013. Incidence was disproportionately higher among white newborns (12, 95% CI 11.0,13.0) and Medicaid enrollees (13.2, 95% CI 11.0,15.0). Southern Nevada had the highest incidence rate of 8.2 per 1000 hospital births. Nearly 75% of NAS cases were residents of Clark County. Incidence rates of NAS parallel the growing opioid prescription rates in Nevada and highlight the need for adopting opioid control prescribing practices to combat this drug epidemic. These findings might help in designing and evaluating state- and system-level interventions introduced to combat the opioid epidemic.
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影响因子：
1.7
作者：
Midi, Habshah;Sarkar, S. K.;Rana, Sohel
通讯作者：
Rana, Sohel
影响因子：
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作者：
Ko, Jean Y.;Patrick, Stephen W.;Barfield, Wanda D.
通讯作者：
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影响因子：
120.7
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DOI：
10.1001/jama.2016.1464
发表时间：
2016-04-19
期刊：
JAMA
影响因子：
--
作者：
Dowell D;Haegerich TM;Chou R
通讯作者：
Chou R
影响因子：
1.5
作者：
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通讯作者：
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