The characteristics of thoracic aortic dissection in autopsy-diagnosed individuals: An autopsy study.
The characteristics of thoracic aortic dissection in autopsy-diagnosed individuals: An autopsy study.
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尸检诊断个体胸主动脉夹层的特征：尸检研究
DOI：
10.3389/fcvm.2022.973530
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发表时间：
2022
影响因子：
3.6
通讯作者：
Cheng, Jianding
中科院分区：
文献类型：
--
作者：
Zhao, Qianhao;Yin, Kun;Zhou, Nan;Wu, Qiuping;Xiao, Yuxi;Zheng, Jinxiang;Zheng, Da;Bi, Qiming;Quan, Li;Hu, Bingjie;Cheng, Jianding
胸主动脉夹层是与主动脉疾病相关的心脏性猝死的最常见原因。法医学研究中的精神分裂症受害者的年龄明显小于住院的精神分裂症患者，而只有少数研究是对尸检诊断的精神分裂症死者进行的。中山大学法医学中心于1999年至2019年进行了一项回顾性研究，以解决吸毒受害者的特征。共评估了200例自发性脑出血死亡病例，其中男性165例（82.5%），斯坦福大学A型175例（87.5%）。我们的主要研究结果表明，与在其一生中诊断出的糖尿病患者相比，在尸检前诊断出糖尿病的个体显示出更早的发病年龄（43.80岁）和更少的伴发高血压（<50%）。猝死是32例死者的首发症状。腹痛（59例死亡）是最常见的初始症状，而不是胸/背痛（40例死亡），42例死亡没有伴随疼痛。腹痛和无痛症状的比例越高，误诊的风险越高。女性比男性表现出更不典型的临床表现和快速进展。年轻的死者表现出更明显的左心变化。本研究将尸检前诊断的TAD患者作为一个特殊的个体，表明迫切需要进一步研究非典型疼痛和无痛或年龄较小的TAD患者的早期诊断和发病机制，以减少TAD相关猝死的负担。
Thoracic aortic dissection (TAD) is the most common cause of sudden cardiac death associated with aortic diseases. The age of TAD victims in forensic studies is significantly younger than hospitalized patients with TAD, while only a few studies have been conducted on autopsy-diagnosed TAD deceased. A retrospective study was conducted at the Medicolegal Center of Sun Yat-sen University from 1999 to 2019 to address the characteristics of TAD victims. A total of 200 deceased from spontaneous rupture of TAD were assessed, with 165 (82.5%) males and 175 (87.5%) Stanford type A deceased. Our main results showed that compared with patients with TAD diagnosed during their lifetime, individuals diagnosed with TAD until an autopsy showed an earlier onset (43.80 years old) and less accompanied hypertension (<50%). Sudden death was the initial symptom of 32 decedents. Instead of chest/back pain (40 decedents), abdominal pain (59 decedents) was the most common initial symptom, and 42 decedents presented with no accompanying pain. A higher proportion of abdominal pain and the painless symptom was associated with a higher risk of misdiagnosis. Women showed a more atypical clinical presentation and rapid progression than men. Younger decedents showed more pronounced left heart changes. The present study implicated the TAD individuals diagnosed until an autopsy as a particular entity, indicating the urgent need for further investigation on early diagnosis and pathogenesis of patients with TAD with atypical pain and painless or with younger age to reduce the burden of TAD-related sudden death.
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影响因子：
81.5
作者：
Nienaber, Christoph A.;Clough, Rachel E.;Pepper, John
通讯作者：
Pepper, John
年龄对中国急性主动脉夹层患者临床表现、治疗选择和结果的影响
影响因子：
1.5
作者：
Huang, Bi;Chen, Zhaoran;Fan, Xiaohan
通讯作者：
Fan, Xiaohan
DOI：
10.1016/s1078-5884(98)80205-0
发表时间：
1998-05-01
影响因子：
5.7
作者：
Ballaro, A;Cortina-Borja, M;Collin, J
通讯作者：
Collin, J
影响因子：
1.6
作者：
Maitusong B;Sun HP;Xielifu D;Mahemuti M;Ma X;Liu F;Xie X;Azhati A;Zhou XR;Ma YT
通讯作者：
Ma YT
影响因子：
1.8
作者：
Asouhidou I;Asteri T
通讯作者：
Asteri T