A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
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DOI：
10.1038/ng.3094
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发表时间：
2014-10
期刊：
影响因子：
30.8
通讯作者：
Haiman, Christopher A.
中科院分区：
文献类型：
--
作者：
Al Olama, Ali Amin;Kote-Jarai, Zsofia;Berndt, Sonja I.;Conti, David V.;Schumacher, Fredrick;Han, Ying;Benlloch, Sara;Hazelett, Dennis J.;Wang, Zhaoming;Saunders, Ed;Leongamornlert, Daniel;Lindstrom, Sara;Jugurnauth-Little, Sara;Dadaev, Tokhir;Tymrakiewicz, Malgorzata;Stram, Daniel O.;Rand, Kristin;Wan, Peggy;Stram, Alex;Sheng, Xin;Pooler, Loreall C.;Park, Karen;Xia, Lucy;Tyrer, Jonathan;Kolonel, Laurence N.;Le Marchand, Loic;Hoover, Robert N.;Machiela, Mitchell J.;Yeager, Merideth;Burdette, Laurie;Chung, Charles C.;Hutchinson, Amy;Yu, Kai;Goh, Chee;Ahmed, Mahbubl;Govindasami, Koveela;Guy, Michelle;Tammela, Teuvo L. J.;Auvinen, Anssi;Wahlfors, Tlina;Schleutker, Johanna;Visakorpi, Tapio;Leinonen, Katri A.;Xu, Jianfeng;Aly, Markus;Donovan, Jenny;Travis, Ruth C.;Key, Tim J.;Siddiq, Afshan;Canzian, Federico;Khaw, Kay-Tee;Takahashi, Atsushi;Kubo, Michiaki;Pharoah, Paul;Pashayan, Nora;Weischer, Maren;Nordestgaard, Borge G.;Nielsen, Sune F.;Klarskov, Peter;Roder, Martin Andreas;Iversen, Peter;Thibodeau, Stephen N.;McDonnell, Shannon K.;Schaid, Daniel J.;Stanford, Janet L.;Kolb, Suzanne;Holt, Sarah;Knudsen, Beatrice;Coll, Antonio Hurtado;Gapstur, Susan M.;Diver, W. Ryan;Stevens, Victoria L.;Maier, Christiane;Luedeke, Manuel;Herkommer, Kathleen;Rinckleb, Antje E.;Strom, Sara S.;Pettaway, Curtis;Yeboah, Edward D.;Tettey, Yao;Biritwum, Richard B.;Adjei, Andrew A.;Tay, Evelyn;Truelove, Ann;Niwa, Shelley;Choklcalingam, Anand P.;Cannon-Albright, Lisa;Cybulski, Cezary;Wokolorczyk, Dominika;Kluzniak, Wojciech;Park, Jong;Sellers, Thomas;Lin, Hui-Yi;Isaacs, William B.;Partin, Alan W.;Brenner, Hermann;Dieffenbach, Aida Karina;Stegmaier, Christa;Chen, Constance;Giovannucci, Edward L.;Ma, Jing;Stampfer, Meir;Penney, Kathryn L.;Mucci, Lorelei;John, Esther M.;Ingles, Sue A.;Kittles, Rick A.;Murphy, Adam B.;Pandha, Hardev;Michael, Agnieszka;Kierzek, Andrzej M.;Blot, William;Signorello, Lisa B.;Zheng, Wei;Albanes, Demetrius;Virtamo, Jarmo;Weinstein, Stephanie;Nemesure, Barbara;Carpten, John;Leske, Cristina;Wu, Suh-Yuh;Hennis, Anselm;Kibel, Adam S.;Rybicki, Benjamin A.;Neslund-Dudas, Christine;Hsing, Ann W.;Chu, Lisa;Goodman, Phyllis J.;Klein, Eric A.;Zheng, S. Lilly;Batra, Jyotsna;Clements, Judith;Spurdle, Amanda;Teixeira, Manuel R.;Paulo, Paula;Maia, Sofia;Slavov, Chavdar;Kaneva, Radka;Mitev, Vanio;Witte, John S.;Casey, Graham;Gillanders, Elizabeth M.;Seminara, Daniella;Riboli, Elio;Hamdy, Freddie C.;Coetzee, Gerhard A.;Li, Qiyuan;Freedman, Matthew L.;Hunter, David J.;Muir, Kenneth;Gronberg, Henrik;Nea, David E.;Southey, Melissa;Giles, Graham G.;Severi, Gianluca;Cook, Michael B.;Nakagawa, Hidewaki;Wiklund, Fredrik;Kraft, Peter;Chanock, Stephen J.;Henderson, Brian E.;Easton, Douglas F.;Eeles, Rosalind A.;Haiman, Christopher A.
全基因组关联研究（GWAS）已经确定了76种与前列腺癌风险相关的变异，主要发生在欧洲血统的人群中。为了确定这种常见癌症的其他易感基因座，我们对来自欧洲，非洲，日本和拉丁美洲血统人群的43，303例前列腺癌病例和43，737例对照进行了超过1000万个SNP的荟萃分析。在P<5×10-8时发现了23个新的易感基因座;在欧洲血统的男性中发现了15个变异，7个来自多种族分析，1个与早发性前列腺癌相关。这23种变异与已知的前列腺癌风险变异相结合，解释了欧洲血统人群中33%的疾病家族风险。这些发现为研究前列腺癌的发病机制提供了新的领域，并证明了将祖先不同的人群结合起来发现疾病风险位点的实用性。
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three novel susceptibility loci were revealed at P<5×10-8; 15 variants were identified among men of European ancestry, 7 from multiethnic analyses and one was associated with early-onset prostate cancer. These 23 variants, in combination with the known prostate cancer risk variants, explain 33% of the familial risk of the disease in European ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the utility of combining ancestrally diverse populations to discover risk loci for disease.
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影响因子：
30.8
作者：
Shete S;Hosking FJ;Robertson LB;Dobbins SE;Sanson M;Malmer B;Simon M;Marie Y;Boisselier B;Delattre JY;Hoang-Xuan K;El Hallani S;Idbaih A;Zelenika D;Andersson U;Henriksson R;Bergenheim AT;Feychting M;Lönn S;Ahlbom A;Schramm J;Linnebank M;Hemminki K;Kumar R;Hepworth SJ;Price A;Armstrong G;Liu Y;Gu X;Yu R;Lau C;Schoemaker M;Muir K;Swerdlow A;Lathrop M;Bondy M;Houlston RS
通讯作者：
Houlston RS
DOI：
10.1158/1055-9965.epi-12-0598
发表时间：
2012-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cheng I;Chen GK;Nakagawa H;He J;Wan P;Laurie CC;Shen J;Sheng X;Pooler LC;Crenshaw AT;Mirel DB;Takahashi A;Kubo M;Nakamura Y;Al Olama AA;Benlloch S;Donovan JL;Guy M;Hamdy FC;Kote-Jarai Z;Neal DE;Wilkens LR;Monroe KR;Stram DO;Muir K;Eeles RA;Easton DF;Kolonel LN;Henderson BE;Le Marchand L;Haiman CA
通讯作者：
Haiman CA
影响因子：
30.8
作者：
通讯作者：
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影响因子：
30.8
作者：
通讯作者：
--
影响因子：
3.5
作者：
Schumacher, Fredrick R.;Berndt, Sonja I.;Kraft, Peter
通讯作者：
Kraft, Peter