Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
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为了寻找可能导致非洲裔男性前列腺癌高发病率的常见风险等位基因，我们进行了一项全基因组关联研究(Gwas)，在3425例非裔美国人前列腺癌病例和3290名非洲裔美国男性对照中检测了1,047,986个单核苷酸多态(SNP)标记。第一阶段中最重要的17个新关联在1,844个病例和3,269个非洲血统对照中进行了随访。我们在染色体17q21上发现了一个新的危险变异(rs7210100；每等位基因的优势比=1.51；p=3.4×10−13)。风险等位基因在非洲裔男性中的频率为~5%，而在其他人群中很少见(1%)。需要进一步的研究来调查该等位基因对前列腺癌风险的生物学贡献。这些研究结果强调了在不同人群中开展全球气候变化研究的重要性。
In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study (GWAS), with 1,047,986 single nucleotide polymorphism (SNP) markers examined in 3,425 African American prostate cancer cases and 3,290 African American male controls. The most significant 17 novel associations in stage 1 were followed-up in 1,844 cases and 3,269 controls of African ancestry. We identified a novel risk variant on chromosome 17q21 (rs7210100; odds ratio per allele=1.51; p=3.4×10−13). The frequency of the risk allele is ~5% in men of African descent while it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting GWAS in diverse populations.
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