Cytochrome P-450 mediated interaction between hydroperoxide and molecular oxygen. A proposed method for P-450 kinetic studies.

Cytochrome P-450 mediated interaction between hydroperoxide and molecular oxygen. A proposed method for P-450 kinetic studies.
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细胞色素 P-450 介导氢过氧化物和分子氧之间的相互作用。

DOI:
10.1016/0006-291x(83)91198-1
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发表时间:
1983
影响因子:
3.1
通讯作者:
E. Wheeler
E. Wheeler
中科院分区:
生物学4区
文献类型:
--
作者:
E. Wheeler

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大鼠肝细胞色素P-450介导等摩尔量溶解氧和有机氢过氧化物之间的新反应。该反应具有依赖于NADPH-O2的羟基化和不依赖于NADPH-O2的过氧化物酶反应的一些特性,但不需要NADPH、磷脂酰胆碱或除氢过氧化物和氧以外的任何底物。它以比其他众所周知的P-450羟基化反应快约100倍的速率进行。在这种新的反应中监测O2消耗速率可能是一种简单而快速的方法,用于研究细胞色素P-450的动力学。
Rat liver cytochrome P-450 mediates a novel reaction between equimolar quanitities of dissolved oxygen and organic hydroperoxides. The reaction shares some of the properties of both NADPH-O2dependent hydroxylation and NADPH-O2independent peroxidase reactions, but does not require either NADPH, phosphatidylcholine, or any substrates other than hydroperoxide and oxygen. It proceeds at a rate approximately 100 times faster than other well known P-450 hydroxylation reactions. Monitoring the rate of O2consumption in this novel reaction may be a simple and rapid means for studying the kinetics of cytochrome P-450.
DOI: 10.1042/bj1950761
发表时间: 1981-01-01
影响因子: 4.1
作者:
DEMONTELLANO, PRO;MATHEWS, JM
通讯作者: MATHEWS, JM
肝微粒体细胞色素 P-450 的电泳均质组成形式的特性。
DOI: --
发表时间: 1981
期刊: The Journal of biological chemistry
影响因子: --
作者:
Koop,DR;Persson,AV;Coon,MJ
通讯作者: Coon,MJ
自杀底物选择性失活细胞色素 P-450 同工酶。
DOI: 10.1016/0003-9861(81)90239-3
发表时间: 1981
影响因子: 3.9
作者:
OrtizdeMontellano,PR;Mico,BA;Mathews,JM;Kunze,KL;Miwa,GT;Lu,AY
通讯作者: Lu,AY