Gut-liver crosstalk in sepsis-induced liver injury.
Gut-liver crosstalk in sepsis-induced liver injury.
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DOI：
10.1186/s13054-020-03327-1
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发表时间：
2020-10-19
期刊：
影响因子：
--
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Sun J;Zhang J;Wang X;Ji F;Ronco C;Tian J;Yin Y
脓毒症的特征在于对感染的免疫应答失调，导致危及生命的器官功能障碍。脓毒症引起的肝损伤被认为是重症监护病房死亡率的一个强有力的独立预测因素。在全身感染期间，肝脏通过细菌清除、急性期蛋白（APP）和细胞因子的产生以及对炎症的代谢适应来调节免疫防御。炎性细胞因子水平的增加和细菌清除受损以及代谢产物的破坏可导致肠道微生物群生态失调和肠粘膜屏障的破坏。肠道微生物群的变化在脓毒症期间的肝损伤中起着至关重要的作用。细菌移位和由此产生的肠道炎症导致全身炎症反应和急性肝损伤。肠-肝串扰是治疗干预的潜在靶点。本文就脓毒症肝损伤中肠-肝串扰的机制作一综述。
Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality in the intensive care unit. During systemic infections, the liver regulates immune defenses via bacterial clearance, production of acute-phase proteins (APPs) and cytokines, and metabolic adaptation to inflammation. Increased levels of inflammatory cytokines and impaired bacterial clearance and disrupted metabolic products can cause gut microbiota dysbiosis and disruption of the intestinal mucosal barrier. Changes in the gut microbiota play crucial roles in liver injury during sepsis. Bacterial translocation and resulting intestinal inflammation lead to a systemic inflammatory response and acute liver injury. The gut-liver crosstalk is a potential target for therapeutic interventions. This review analyzes the underlying mechanisms for the gut-liver crosstalk in sepsis-induced liver injury.
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