Intestinal permeability--a new target for disease prevention and therapy.
Intestinal permeability--a new target for disease prevention and therapy.
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DOI：
10.1186/s12876-014-0189-7
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发表时间：
2014-11-18
影响因子：
2.4
通讯作者：
Wells JM
中科院分区：
文献类型：
--
作者：
Bischoff SC;Barbara G;Buurman W;Ockhuizen T;Schulzke JD;Serino M;Tilg H;Watson A;Wells JM
越来越多的数据强调肠道屏障和肠道通透性对健康和疾病的重要作用。然而，这些术语的定义很差，它们的评估是一个有争议的问题，它们的临床意义也没有明确确定。本文就黏膜屏障及其在疾病预防和治疗中的作用作一综述。首先，定义相关术语“肠屏障”和“肠通透性”。其次，阐述了影响肠屏障通透性的关键因素。这个屏障代表了一个巨大的粘膜表面，数十亿的细菌面临着我们身体最大的免疫系统。一方面，完整的肠道屏障保护人体免受微生物和毒素的入侵，另一方面，这一屏障必须开放以吸收必需的液体和营养物质。这些相反的目标是通过肠屏障组成的复杂的解剖学和功能结构来实现的，其功能状态由“肠渗透性”描述。第三，描述了饮食和细菌对肠道通透性的调节。特别是，潜在的屏障干扰物，如肠道灌注不足，感染和毒素，以及选定的过量营养素，药物和其他生活方式因素都必须考虑在内。在第四部分中，介绍并批判性地讨论了评估肠道通透性的方法。这些方法差异很大，可能评估屏障的不同功能组件。这一功能实体的自然变异性，取决于物种和基因以及饮食和其他环境因素，进一步阻碍了屏障评估。在最后一部分，我们讨论了与肠道通透性增加相关的选定疾病，如危重病，炎症性肠病，乳糜泻，食物过敏，肠易激综合征，以及最近认识到的肥胖和代谢性疾病。所有这些疾病的特征在于炎症，其可能由管腔组分易位到宿主中引发。总之，作为肠屏障功能特征的肠通透性越来越被认为与健康和疾病相关，因此，该主题值得更多关注。本文的在线版本（doi：10.1186/s12876-014-0189-7）包含补充材料，可供授权用户使用。
Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of debate, and their clinical significance is not clearly established. In the present review, current knowledge on mucosal barrier and its role in disease prevention and therapy is summarized. First, the relevant terms ‘intestinal barrier’ and ‘intestinal permeability’ are defined. Secondly, the key element of the intestinal barrier affecting permeability are described. This barrier represents a huge mucosal surface, where billions of bacteria face the largest immune system of our body. On the one hand, an intact intestinal barrier protects the human organism against invasion of microorganisms and toxins, on the other hand, this barrier must be open to absorb essential fluids and nutrients. Such opposing goals are achieved by a complex anatomical and functional structure the intestinal barrier consists of, the functional status of which is described by ‘intestinal permeability’. Third, the regulation of intestinal permeability by diet and bacteria is depicted. In particular, potential barrier disruptors such as hypoperfusion of the gut, infections and toxins, but also selected over-dosed nutrients, drugs, and other lifestyle factors have to be considered. In the fourth part, the means to assess intestinal permeability are presented and critically discussed. The means vary enormously and probably assess different functional components of the barrier. The barrier assessments are further hindered by the natural variability of this functional entity depending on species and genes as well as on diet and other environmental factors. In the final part, we discuss selected diseases associated with increased intestinal permeability such as critically illness, inflammatory bowel diseases, celiac disease, food allergy, irritable bowel syndrome, and – more recently recognized – obesity and metabolic diseases. All these diseases are characterized by inflammation that might be triggered by the translocation of luminal components into the host. In summary, intestinal permeability, which is a feature of intestinal barrier function, is increasingly recognized as being of relevance for health and disease, and therefore, this topic warrants more attention. The online version of this article (doi:10.1186/s12876-014-0189-7) contains supplementary material, which is available to authorized users.
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影响因子：
11.1
作者：
Amar, Jacques;Chabo, Chantal;Waget, Aurelie;Klopp, Pascale;Vachoux, Christelle;Bermudez-Humaran, Luis G.;Smirnova, Natalia;Berge, Mathieu;Sulpice, Thierry;Lahtinen, Sampo;Ouwehand, Arthur;Langella, Philippe;Rautonen, Nina;Sansonetti, Philippe J.;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
29.4
作者：
Barbara, Giovanni;Wang, Bingxian;Corinaldesi, Roberto
通讯作者：
Corinaldesi, Roberto
影响因子：
2.1
作者：
Anderson, Rachel C.;Cookson, Adrian L.;Roy, Nicole C.
通讯作者：
Roy, Nicole C.
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C