Overview of therapeutic ultrasound applications and safety considerations.
Overview of therapeutic ultrasound applications and safety considerations.
复制标题
DOI：
10.7863/jum.2012.31.4.623
复制
发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Bioeffects Committee of the American Institute of Ultrasound in Medicine
中科院分区：
文献类型：
--
作者：
Miller DL;Smith NB;Bailey MR;Czarnota GJ;Hynynen K;Makin IR;Bioeffects Committee of the American Institute of Ultrasound in Medicine
超声在医学中用于治疗目的的应用多年来一直是超声生物效应的公认和有益的用途。自20世纪50年代以来，约1MHz频率的低功率超声已被广泛应用于诸如肌腱炎或滑囊炎等病症的物理治疗。在20世纪80年代，高压振幅冲击波开始用于机械解决肾结石，“碎石术”迅速取代手术成为最常见的治疗选择。超声能量在治疗中的应用不断扩大，目前已批准的应用包括子宫肌瘤消融、白内障摘除（超声乳化）、手术组织切割和止血、经皮给药和骨折愈合等。可能发生不良生物效应，包括热疗法的烧伤和机械疗法的显著出血（例如，G.碎石术）。在超声生物效应的所有这些治疗应用中，必须仔细考虑标准化、超声剂量测定、受益保证和副作用风险最小化，以确保患者的最佳受益风险比。治疗性超声通常具有明确的益处和风险，因此对临床医生提出了易于处理的安全问题。然而，安全信息可能分散、混乱或存在商业利益冲突。管理这个问题的最重要的是由权威团体（如AIUM）向医学超声界传达实际安全信息。在这篇综述中，生物效应委员会概述了广泛的治疗性超声方法，这些方法正在临床使用或正在研究中，并为确保治疗性超声安全性提供了一般指导。
Applications of ultrasound in medicine for therapeutic purposes have been an accepted and beneficial use of ultrasonic biological effects for many years. Low power ultrasound of about 1 MHz frequency has been widely applied since the 1950s for physical therapy in conditions such as tendinitis or bursitis. In the 1980s, high pressure-amplitude shockwaves came into use for mechanically resolving kidney stones, and “lithotripsy” rapidly replaced surgery as the most frequent treatment choice. The use of ultrasonic energy for therapy continues to expand, and approved applications now include uterine fibroid ablation, cataract removal (phacoemulsification), surgical tissue cutting and hemostasis, transdermal drug delivery, and bone fracture healing, among others. Undesirable bioeffects can occur including burns for thermal-based therapies and significant hemorrhage for mechanical-based therapies (e. g. lithotripsy). In all these therapeutic applications for bioeffects of ultrasound, standardization, ultrasound dosimetry, benefits assurance and side-effects risk minimization must be carefully considered in order to insure an optimal benefit to risk ratio for the patient. Therapeutic ultrasound typically has well-defined benefits and risks, and therefore presents a tractable safety problem to the clinician. However, safety information can be scattered, confusing or subject to commercial conflict of interest. Of paramount importance for managing this problem is the communication of practical safety information by authoritative groups, such as the AIUM, to the medical ultrasound community. In this overview, the Bioeffects Committee outlines the wide range of therapeutic ultrasound methods, which are in clinical use or under study, and provides general guidance for assuring therapeutic ultrasound safety.
登录
查看更多内容
影响因子：
2.9
作者：
Canney, Michael S.;Khokhlova, Vera A.;Bessonova, Olga V.;Bailey, Michael R.;Crum, Lawrence A.
通讯作者：
Crum, Lawrence A.
影响因子：
13.8
作者：
Alam, Murad;White, Lucile E.;West, Dennis P.
通讯作者：
West, Dennis P.
影响因子：
2.9
作者：
Anand, Ajay;Kaczkowski, Peter J.
通讯作者：
Kaczkowski, Peter J.
影响因子：
8.3
作者：
Daffertshofer, M;Gass, A;Hennerici, MG
通讯作者：
Hennerici, MG
影响因子：
3.5
作者：
Curiel, Laura;Huang, Yuexi;Hynynen, Kullervo
通讯作者：
Hynynen, Kullervo