Effect of ovariectomy on external urethral sphincter activity in anesthetized female rats.
Effect of ovariectomy on external urethral sphincter activity in anesthetized female rats.
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DOI：
10.1016/j.juro.2011.03.035
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
de Groat WC
中科院分区：
文献类型：
--
作者：
Cheng CL;de Groat WC
绝经后低雌激素状态与各种下尿路功能障碍有关，包括频率、紧迫感、压力性尿失禁和反复尿路感染。我们确定卵巢切除后低雌激素引起的下尿路功能障碍是否也与外括约肌活动的改变有关。雌性SD大鼠行双侧卵巢切除，假手术组大鼠为对照组。分别于假手术或双侧卵巢摘除后4、6、12周和雌激素治疗的双侧卵巢切除大鼠6周后，监测膀胱测膀胱术和外括约肌电活动。排尿反射是在假手术和双侧卵巢切除、氨基甲酸乙酯麻醉动物中诱发的。双侧卵巢切除4~12周大鼠排尿后残余尿量增加，排尿效率降低。双侧卵巢切除后，外括约肌肌电活动的静止期明显缩短，且随时间延长呈递增趋势。这些效应可以通过雌二醇治疗来预防。去卵巢大鼠的外括约肌肌电静止期缩短，表明外括约肌与逼尿肌之间的协调失调可减少尿流，进而降低排尿效率。雌激素替代疗法逆转了这些变化，表明负责逼尿肌-括约肌协调的中央通路受到性腺激素的调节。
The postmenopausal hypoestrogen condition is associated with various lower urinary tract dysfunctions, including frequency, urgency, stress urinary incontinence and recurrent urinary infection. We determined whether hypoestrogen induced lower urinary tract dysfunction after ovariectomy is also associated with an alteration in external urethral sphincter activity. Bilateral ovariectomy was performed in female Sprague-Dawley® rats and sham operated rats served as controls. Transvesical cystometry and external urethral sphincter electromyogram activity were monitored 4, 6 and 12 weeks after sham operation or bilateral ovariectomy and at 6 weeks in bilaterally ovariectomized rats treated with estrogen. The micturition reflex was elicited in sham operated and bilaterally ovariectomized, urethane anesthetized animals. Post-void residual urine increased and voiding efficiency decreased in rats with 4 to 12 weeks of bilateral ovariectomy. The silent period of external urethral sphincter electromyogram activity was shortened significantly and progressively at increased times after bilateral ovariectomy. These effects were prevented by estradiol treatment. As evidenced by shortening of the external urethral sphincter electromyogram silent period in ovariectomized rats, the disruption of coordination between the external urethral sphincter and the detrusor muscle could decrease urine outflow and in turn voiding efficiency. Estrogen replacement reverses these changes, suggesting that the central pathways responsible for detrusor-sphincter coordination are modulated by gonadal hormones.
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