Glaucoma-related adverse events in the Infant Aphakia Treatment Study: 1-year results.
Glaucoma-related adverse events in the Infant Aphakia Treatment Study: 1-year results.
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DOI：
10.1001/archophthalmol.2011.347
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发表时间：
2012-03
影响因子：
--
通讯作者：
Lambert, Scott R.
中科院分区：
文献类型：
--
作者：
Beck, Allen D.;Freedman, Sharon F.;Lynn, Michael J.;Bothun, Erick;Neely, Daniel E.;Lambert, Scott R.
报告婴儿无晶状体眼治疗研究（IATS）中青光眼和疑似青光眼的发生率。在第一年随访中，评价IATS中发生脑胶质瘤相关不良事件的风险因素。114名患有单侧先天性白内障的婴儿被分配接受1至6个月大的白内障手术，其中有（IOL）或没有IOL植入（CL）。青光眼和疑似青光眼的标准化定义被创建并用于IATS。10例患者（9%）发生青光眼，4例患者（4%）疑似青光眼，共14例患者（12%）在第一年随访时接受治疗的眼睛发生青光眼相关不良事件。5例CL患者（9%）和9例IOL患者（16%）发生了青光眼相关不良事件。患有持续性胎儿血管系统（PFV）的儿童发生青光眼相关不良事件的几率高3.1倍，白内障手术时年龄越小，发生青光眼相关不良事件的几率越高1.6倍。现代手术技术不能消除先天性白内障术后早期青光眼的发展，无论是否有人工透镜。有或没有PFV的年轻患者似乎更有可能在随访的第一年发生青光眼相关的不良事件。在先天性白内障手术后，需要警惕青光眼的早期发展，特别是在婴儿早期或PFV时进行手术。IATS的5年随访数据可能会揭示更多的脑肿瘤相关不良事件。
To report the incidence of glaucoma and glaucoma suspects in the Infant Aphakia Treatment Study (IATS). To evaluate risk factors for the development of a glaucoma-related adverse event in IATS in the first year of follow-up. 114 infants with a unilateral congenital cataract were assigned to undergo cataract surgery between 1 to 6 months of age either with (IOL) or without IOL implantation (CL). Standardized definitions of glaucoma and glaucoma suspect were created and used in the IATS. Ten patients (9%) developed glaucoma and 4 patients (4%) were glaucoma suspects for a total of 14 patients (12%) with a glaucoma-related adverse event in the treated eye through the first year of follow-up. Five CL patients (9%) and 9 IOL patients (16%) developed a glaucoma-related adverse event. The odds of developing a glaucoma-related adverse event was 3.1 times higher for a child with persistent fetal vasculature (PFV), and 1.6 times higher for each month of age younger at cataract surgery. Modern surgical techniques do not eliminate the early development of glaucoma following congenital cataract surgery with or without an intraocular lens. Younger patients with or without PFV seem more likely to develop a glaucoma-related adverse event in the first year of follow-up.Vigilance for the early development of glaucoma is needed following congenital cataract surgery, especially when surgery is performed during early infancy or with PFV. Five year follow-up data for the IATS will likely reveal more glaucoma-related adverse events.
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影响因子：
1.6
作者：
Lambert, SR;Lynn, M;Fawcett, SL
通讯作者：
Fawcett, SL
影响因子：
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作者：
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影响因子：
4.2
作者：
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通讯作者：
Hattenbach, Lars-Olof
影响因子：
--
作者：
Chen, TC;Walton, DS;Bhatia, LS
通讯作者：
Bhatia, LS