Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
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DOI：
10.1038/s41385-018-0096-2
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发表时间：
2019-01
影响因子：
8
通讯作者：
Herbert DR
中科院分区：
文献类型：
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作者：
Hung LY;Sen D;Oniskey TK;Katzen J;Cohen NA;Vaughan AE;Nieves W;Urisman A;Beers MF;Krummel MF;Herbert DR
巨噬细胞和上皮细胞之间的协调作用被认为是伤口愈合的必要条件，但巨噬细胞衍生的修复分子尚未明确定义。这项工作表明，肺巨噬细胞依赖三叶因子2来促进无菌损伤、巴西尼波圆线虫或硫酸博莱霉素引起的上皮细胞增殖。出乎意料的是，T、B或ILC群体的存在对于巨噬细胞驱动的修复并不是必需的。相反，在骨髓限制性CD11cCre TFF2 flox小鼠中，条件缺失TFF2加重了肺部病理，并降低了CD45−EpCAM+ pro-SPC+肺泡2型细胞的增殖扩张。TFF2缺失的巨噬细胞降低了Wnt基因Wnt4和Wnt16的表达，用rWnt4和Wnt16重建的钩虫感染的CD11cCre TFF2 flox小鼠恢复了肺上皮损伤后的增殖缺陷。这些数据揭示了一个以前未被认识的机制，其中肺髓性吞噬细胞利用TFF2/Wnt轴作为肺损伤后驱动上皮细胞增殖的机制。
Coordinated efforts between macrophages and epithelia are considered essential for wound healing, but the macrophage-derived molecules responsible for repair are poorly defined. This work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial proliferation following damage caused by sterile wounding, Nippostrongylus brasiliensis or Bleomycin sulfate. Unexpectedly, the presence of T, B, or ILC populations was not essential for macrophage-driven repair. Instead, conditional deletion of TFF2 in myeloid-restricted CD11cCre TFF2 flox mice exacerbated lung pathology and reduced the proliferative expansion of CD45− EpCAM+ pro-SPC+ alveolar type 2 cells. TFF2 deficient macrophages had reduced expression of the Wnt genes Wnt4 and Wnt16 and reconstitution of hookworm-infected CD11cCre TFF2 flox mice with rWnt4 and Wnt16 restored the proliferative defect in lung epitheliapost-injury. These data reveal a previously unrecognized mechanism wherein lung myeloid phagocytes utilize a TFF2/Wnt axis as a mechanism that drives epithelial proliferation following lung injury.
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DOI：
10.1016/s0167-4781(00)00013-0
发表时间：
2000-02-29
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Al-azzeh, ED;Fegert, P;Gött, P
通讯作者：
Gött, P
影响因子：
16.6
作者：
Dubeykovskaya Z;Si Y;Chen X;Worthley DL;Renz BW;Urbanska AM;Hayakawa Y;Xu T;Westphalen CB;Dubeykovskiy A;Chen D;Friedman RA;Asfaha S;Nagar K;Tailor Y;Muthupalani S;Fox JG;Kitajewski J;Wang TC
通讯作者：
Wang TC
DOI：
10.1084/jem.20091268
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Herbert DR;Yang JQ;Hogan SP;Groschwitz K;Khodoun M;Munitz A;Orekov T;Perkins C;Wang Q;Brombacher F;Urban JF Jr;Rothenberg ME;Finkelman FD
通讯作者：
Finkelman FD
影响因子：
2.7
作者：
Caprioli A;Villasenor A;Wylie LA;Braitsch C;Marty-Santos L;Barry D;Karner CM;Fu S;Meadows SM;Carroll TJ;Cleaver O
通讯作者：
Cleaver O
影响因子：
82.9
作者：
通讯作者：
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