Toxic element contamination of natural health products and pharmaceutical preparations.
Toxic element contamination of natural health products and pharmaceutical preparations.
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DOI：
10.1371/journal.pone.0049676
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Rodushkin I
中科院分区：
文献类型：
--
作者：
Genuis SJ;Schwalfenberg G;Siy AK;Rodushkin I
最近出现了关于天然保健产品（NHPs）的安全性的担忧-各种保健提供者（包括传统医生）越来越多地推荐这种疗法。认识到大多数人在西方世界现在消费维生素和许多采取草药剂，这项研究endeedly，以确定有毒元素污染的水平范围内的NHP。对121种NHP（包括阿育吠陀，传统中国和各种海洋来源的产品）以及49种常规处方药物制剂进行了有毒元素检测。还对一种产前补充剂的几个批次进行了测试，每个批次中测试了多个样品。将结果与现有的毒物监管限值进行比较。在许多补充剂和药物中发现了有毒元素污染;仅在一小部分测试的NHP中发现了超过既定限度的水平，并且没有测试的药物。一些国家卫生点的汞、镉、铅、砷或铝的污染水平超过了首选的每日终点。中国制造的国家卫生产品中汞和铝的含量普遍较高。由于一些受污染的NHP，经常发生接触有毒元素的情况。质量控制的最佳实践-由NHP行业在政府监督下开发和实施-建议保护不知情消费者的安全。
Concern has recently emerged regarding the safety of natural health products (NHPs)–therapies that are increasingly recommended by various health providers, including conventional physicians. Recognizing that most individuals in the Western world now consume vitamins and many take herbal agents, this study endeavored to determine levels of toxic element contamination within a range of NHPs. Toxic element testing was performed on 121 NHPs (including Ayurvedic, traditional Chinese, and various marine-source products) as well as 49 routinely prescribed pharmaceutical preparations. Testing was also performed on several batches of one prenatal supplement, with multiple samples tested within each batch. Results were compared to existing toxicant regulatory limits. Toxic element contamination was found in many supplements and pharmaceuticals; levels exceeding established limits were only found in a small percentage of the NHPs tested and none of the drugs tested. Some NHPs demonstrated contamination levels above preferred daily endpoints for mercury, cadmium, lead, arsenic or aluminum. NHPs manufactured in China generally had higher levels of mercury and aluminum. Exposure to toxic elements is occurring regularly as a result of some contaminated NHPs. Best practices for quality control–developed and implemented by the NHP industry with government oversight–is recommended to guard the safety of unsuspecting consumers.
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影响因子：
158.5
作者：
BRENNAN, TA;LEAPE, LL;HIATT, HH
通讯作者：
HIATT, HH
影响因子：
5.7
作者：
Buettner, Catherine;Mukamal, Kenneth J.;Mittleman, Murray A.
通讯作者：
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影响因子：
3.9
作者：
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通讯作者：
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影响因子：
4.7
作者：
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通讯作者：
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影响因子：
6.9
作者：
Cao, Hongbin;Chen, Jianjiang;Men, Yi
通讯作者：
Men, Yi