Immunopathology of toxic epidermal necrolysis. Keratinocytes, HLA-DR expression, Langerhans cells, and mononuclear cells: an immunopathologic study of five cases.
Immunopathology of toxic epidermal necrolysis. Keratinocytes, HLA-DR expression, Langerhans cells, and mononuclear cells: an immunopathologic study of five cases.
复制标题
中毒性表皮坏死松解症的免疫病理学。
作者：
G. Villada;J. Roujeau;T. Clérici;I. Bourgault;J. Revuz
背景
BACKGROUND
Toxic epidermal necrolysis is a potentially severe mucocutaneous affliction whose cause is usually drug related. To further characterize the nature of the dermal mononuclear infiltrate as well as the epidermal alterations observed by standard microscopy, we studied five cases of toxic epidermal necrolysis using labeled monoclonal antibodies.
RESULTS
On clinically involved areas of skin, the following occurs: (1) the dermal infiltrate is composed mainly of activated T lymphocytes, with a predominant helper phenotype; (2) the number of Langerhans cells is decreased; and (3) keratinocytes express HLA-DR molecules, normally absent on their surface.
CONCLUSIONS
These findings, although not specific, are consistent with an immune cellular reaction, but they could also be linked to an inflammatory reaction initiated by epidermal damages whatever its primary mechanism.
同种异体和自体骨髓移植患者病变皮肤中的 T 淋巴细胞亚群。
影响因子：
--
作者：
Paller,AS;Nelson,A;Steffen,L;Gottschalk,L;Kaizer,H
通讯作者：
Kaizer,H
培养的人角质形成细胞中 HLA-DR 合成的研究。
DOI：
10.1111/1523-1747.ep12455746
发表时间：
1986
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Wikner,NE;Huff,JC;Norris,DA;Boyce,ST;Cary,M;Kissinger,M;Weston,WL
通讯作者：
Weston,WL