Adverse obstetric and perinatal outcomes following treatment of adolescent and young adult cancer: a population-based cohort study.
Adverse obstetric and perinatal outcomes following treatment of adolescent and young adult cancer: a population-based cohort study.
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DOI：
10.1371/journal.pone.0113292
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Einarsdottir K
中科院分区：
文献类型：
--
作者：
Haggar FA;Pereira G;Preen D;Holman CD;Einarsdottir K
调查青少年和青年癌症（AYA）女性幸存者及其后代的产科和围产期结局。使用全州相关数据的多变量分析，将1982-2007年期间西澳大利亚州诊断为AYA癌症的女性幸存者中所有首次完成妊娠的结果（n = 1894）与没有癌症病史的女性进行比较。对照妊娠与母亲的年龄、胎次和分娩年份相匹配。与非癌症组相比，AYA癌女性幸存者先兆流产（校正相对危险度2.09,95%置信区间1.51 ~ 2.74）、妊娠期糖尿病（校正相对危险度2.65,2.08 ~ 3.57）、先兆子痫（校正相对危险度1.32,1.04 ~ 1.87）、产后出血（校正相对危险度2.83,1.92 ~ 4.67）、剖宫产（校正相对危险度2.62,2.22 ~ 3.04）、产妇产后住院5 d（校正相对危险度3.01,1.72 ~ 5.58）的风险增加，但先兆早产、产前出血、胎膜早破，难产或胎盘残留。其子代早产（<37周：1.68,1.21-2.08）、低出生体重（<2500 g: 1.51, 1.23-2.12）、胎儿生长受限（3.27,2.45-4.56）、1分钟低Apgar评分（<7）（2.83,2.28-3.56）、需要复苏（1.66,1.27-2.19）或特殊护理托儿所入院（1.44,1.13-1.78）的风险增加。在幸存者的后代中，先天性异常和围产期死亡（宫内或出生≤7天）没有增加。AYA癌症的女性幸存者在随后的怀孕中出现不良产科和围产期结局的风险中等，可能需要额外的监测或干预。
To investigate obstetric and perinatal outcomes among female survivors of adolescent and young adult (AYA) cancers and their offspring. Using multivariate analysis of statewide linked data, outcomes of all first completed pregnancies (n = 1894) in female survivors of AYA cancer diagnosed in Western Australia during the period 1982–2007 were compared with those among females with no cancer history. Comparison pregnancies were matched by maternal age-group, parity and year of delivery. Compared with the non-cancer group, female survivors of AYA cancer had an increased risk of threatened abortion (adjusted relative risk 2.09, 95% confidence interval 1.51–2.74), gestational diabetes (2.65, 2.08–3.57), pre-eclampsia (1.32, 1.04–1.87), post-partum hemorrhage (2.83, 1.92–4.67), cesarean delivery (2.62, 2.22–3.04), and maternal postpartum hospitalization>5 days (3.01, 1.72–5.58), but no excess risk of threatened preterm delivery, antepartum hemorrhage, premature rupture of membranes, failure of labor to progress or retained placenta. Their offspring had an increased risk of premature birth (<37 weeks: 1.68, 1.21–2.08), low birth weight (<2500 g: 1.51, 1.23–2.12), fetal growth restriction (3.27, 2.45–4.56), and neonatal distress indicated by low Apgar score (<7) at 1 minute (2.83, 2.28–3.56), need for resuscitation (1.66, 1.27–2.19) or special care nursery admission (1.44, 1.13–1.78). Congenital abnormalities and perinatal deaths (intrauterine or ≤7 days of birth) were not increased among offspring of survivors. Female survivors of AYA cancer have moderate excess risks of adverse obstetric and perinatal outcomes arising from subsequent pregnancies that may require additional surveillance or intervention.
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影响因子：
6.2
作者：
Barr, Ronald D.
通讯作者：
Barr, Ronald D.
DOI：
10.1002/mpo.2950160403
发表时间：
1988-01-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
--
作者：
BYRNE, J;MULVIHILL, JJ;MYERS, MH
通讯作者：
MYERS, MH
影响因子：
5.8
作者：
Blumenfeld, Zeev
通讯作者：
Blumenfeld, Zeev
影响因子：
5
作者：
Ananth, CV;Wilcox, AJ
通讯作者：
Wilcox, AJ
影响因子：
7.2
作者：
Clark, H.;Kurinczuk, J. J.;Bhattacharya, S.
通讯作者：
Bhattacharya, S.