Should global burden of disease estimates include depression as a risk factor for coronary heart disease?
Should global burden of disease estimates include depression as a risk factor for coronary heart disease?
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DOI：
10.1186/1741-7015-9-47
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发表时间：
2011-05-03
期刊：
影响因子：
9.3
通讯作者：
Whiteford HA
中科院分区：
文献类型：
--
作者：
Charlson FJ;Stapelberg NJ;Baxter AJ;Whiteford HA
《2010年全球疾病负担研究》估计了所有主要疾病和伤害造成的过早死亡和残疾。此外，它旨在量化疾病和其他因素在疾病和伤害病因学中的风险。精神障碍和冠心病都是重要的公共卫生问题，因为它们的发病率很高，对全球疾病负担有相当大的贡献。全球疾病负担研究将首次将精神障碍作为冠心病的危险因素进行评估。我们在这里表明，目前的证据满足既定的标准，认为抑郁症是一个独立的危险因素，在冠心病的发展。似乎存在剂量反应关系，并提出了合理的生物学途径。然而，在对文献进行严格评估时存在许多挑战，包括异质性问题，抑郁症和冠心病的定义和测量，发表偏倚和残留混杂。因此，尽管现有数据存在一些局限性，但在新的全球疾病负担研究中，现在将重性抑郁症视为冠心病的危险因素是合适的。
The 2010 Global Burden of Disease Study estimates the premature mortality and disability of all major diseases and injuries. In addition it aims to quantify the risk that diseases and other factors play in the aetiology of disease and injuries. Mental disorders and coronary heart disease are both significant public health issues due to their high prevalence and considerable contribution to global disease burden. For the first time the Global Burden of Disease Study will aim to assess mental disorders as risk factors for coronary heart disease. We show here that current evidence satisfies established criteria for considering depression as an independent risk factor in development of coronary heart disease. A dose response relationship appears to exist and plausible biological pathways have been proposed. However, a number of challenges exist when conducting a rigorous assessment of the literature including heterogeneity issues, definition and measurement of depression and coronary heart disease, publication bias and residual confounding. Therefore, despite some limitations in the available data, it is now appropriate to consider major depression as a risk factor for coronary heart disease in the new Global Burden of Disease Study.
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影响因子：
168.9
作者：
Murray, CJL;Lopez, AD
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.3
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DOI：
10.1016/s0735-1097(00)00804-4
发表时间：
2000-09-01
影响因子：
24
作者：
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通讯作者：
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