Comparative studies on nebulizers for antigen inhalation in experimental asthma
Comparative studies on nebulizers for antigen inhalation in experimental asthma
复制标题
实验性哮喘抗原吸入雾化器的比较研究
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
S. Kohno
中科院分区：
文献类型：
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作者：
T. Nabe;N. Shinoda;K. Yamashita;M. Yamada;H. Yamamura;S. Kohno
在实验动物中，大多数过敏性哮喘病例是由吸入雾状抗原引起的。由于一些物种（包括豚鼠、小鼠和大鼠）天生无法通过口腔呼吸，因此在由抗原吸入引起的实验性哮喘中，上呼吸道反应可能在很大程度上参与其中。考虑到这一点，我们评估了三种类型的雾化器（手工制作的玻璃器皿压力雾化器（GPN）， DeVilbiss雾化器（DN）和超声波雾化器（UN））通过吸入抗原对支气管哮喘豚鼠充分致敏/激发的能力。几种溶液和悬浮液，包括抗原和AI(OH) 3，用这三种雾化器雾化。得到的结果如下：无论使用哪种溶液或悬浮液，在三种雾化器中，GPN产生的雾霭直径最小。产生的雾的中位直径为GPN （1.6 ~ 2.1 μm）。
ABSTRACT The majority of cases of allergic asthma in experimental animals have been provoked by inhalation with mist antigen. Because of the inherent inability of some species to breathe through the mouth, including guinea pigs, mice and rats, an upper airway response may be substantially involved in experimental asthma induced by antigen inhalation. With this in mind, we evaluated three types of nebulizers (a hand-made glassware pressure nebulizer (GPN), a DeVilbiss nebulizer (DN) and an ultrasonic nebulizer (UN)) with respect to their ability to adequately sensitize/challenge guinea pigs by antigen inhalation in bronchial asthma. Several solutions and suspensions, including antigen and AI(OH) 3 , were atomized with these three nebulizers. The results obtained were as follows: irrespective of the type of solution or suspension used, of the three nebulizers, GPN generated mists with the smallest diameter. The rank order of median diameter of the mists generated was GPN (1.6-2.1 μm)
上呼吸道对豚鼠抗原诱导的晚期呼吸道阻塞反应的贡献。
DOI：
10.1164/ajrccm/142.1.138
发表时间：
1990
期刊：
The American review of respiratory disease
影响因子：
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作者：
Johns,K;Sorkness,R;Graziano,F;Castleman,W;LemanskeJr,RF
通讯作者：
LemanskeJr,RF