The Role of Vti1a in Biological Functions and Its Possible Role in Nervous System Disorders.
The Role of Vti1a in Biological Functions and Its Possible Role in Nervous System Disorders.
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DOI：
10.3389/fnmol.2022.918664
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发表时间：
2022
影响因子：
4.8
通讯作者：
Li, Xihong
中科院分区：
文献类型：
--
作者：
Tang, Fajuan;Fan, Jiali;Zhang, Xiaoyan;Zou, Zhuan;Xiao, Dongqiong;Li, Xihong
关键词：
t-SNAREs 1A （Vti1a）是n -乙基酰亚胺敏感因子附着蛋白受体蛋白家族的一员，通过与t-SNAREs 1A （Vti1a）的相互作用进行囊泡运输，作为一种囊泡蛋白参与细胞信号传导并介导囊泡运输。Vti1a似乎在神经元中具有特定的作用，主要通过调节上游神经分泌事件介导胞外蛋白和分泌细胞器的可用性，以及调节自发突触传递和突触后功效来控制神经分泌。Vti1a也在神经发育、自噬和神经元的非常规细胞外转运中发挥重要作用。研究表明，Vti1a功能障碍通过影响自发性神经传递在肝性脑病的病理机制中起关键作用。它也可能在肌萎缩性侧索硬化症中有未知的作用。VTI1A变异与胶质瘤的风险相关，VTI1A基因与邻近的TCF7L2基因的融合产物参与胶质瘤的发展。本文综述了Vti1a在神经元中的功能，并重点介绍了Vti1a在几种神经系统疾病中的作用。
Vesicle transport through interaction with t-SNAREs 1A (Vti1a), a member of the N-ethylmaleimide-sensitive factor attachment protein receptor protein family, is involved in cell signaling as a vesicular protein and mediates vesicle trafficking. Vti1a appears to have specific roles in neurons, primarily by regulating upstream neurosecretory events that mediate exocytotic proteins and the availability of secretory organelles, as well as regulating spontaneous synaptic transmission and postsynaptic efficacy to control neurosecretion. Vti1a also has essential roles in neural development, autophagy, and unconventional extracellular transport of neurons. Studies have shown that Vti1a dysfunction plays critical roles in pathological mechanisms of Hepatic encephalopathy by influencing spontaneous neurotransmission. It also may have an unknown role in amyotrophic lateral sclerosis. A VTI1A variant is associated with the risk of glioma, and the fusion product of the VTI1A gene and the adjacent TCF7L2 gene is involved in glioma development. This review summarizes Vti1a functions in neurons and highlights the role of Vti1a in the several nervous system disorders.
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影响因子：
25
作者：
Fredj, Naila Ben;Burrone, Juan
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