Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens.
Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens.
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DOI：
10.3390/molecules22122223
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发表时间：
2017-12-20
期刊：
影响因子：
--
通讯作者：
Ibrahim AS
中科院分区：
文献类型：
--
作者：
Soliman SSM;Alsaadi AI;Youssef EG;Khitrov G;Noreddin AM;Husseiny MI;Ibrahim AS
The fast development of multi-drug resistant (MDR) organisms increasingly threatens global health and well-being. Plant natural products have been known for centuries as alternative medicines that can possess pharmacological characteristics, including antimicrobial activities. The antimicrobial activities of essential oil (Calli oil) extracted from the Calligonum comosum plant by hydro-steam distillation was tested either alone or when combined with lawsone, a henna plant naphthoquinone, against MDR microbes. Lawsone showed significant antimicrobial activities against MDR pathogens in the range of 200–300 µg/mL. Furthermore, Calli oil showed significant antimicrobial activities against MDR bacteria in the range of 180–200 µg/mL, Candida at 220–240 µg/mL and spore-forming Rhizopus fungus at 250 µg/mL. Calli oil’s inhibition effect on Rhizopus, the major cause of the lethal infection mucormycosis, stands for 72 h, followed by an extended irreversible white sporulation effect. The combination of Calli oil with lawsone enhanced the antimicrobial activities of each individual alone by at least three-fold, while incorporation of both natural products in a liposome reduced their toxicity by four- to eight-fold, while maintaining the augmented efficacy of the combination treatment. We map the antimicrobial activity of Calli oil to its major component, a benzaldehyde derivative. The findings from this study demonstrate that formulations containing essential oils have the potential in the future to overcome antimicrobial resistance.
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影响因子：
7.3
作者：
Nasiri, Hamid Reza;Madej, M. Gregor;Schwalbe, Harald
通讯作者：
Schwalbe, Harald
影响因子：
9.4
作者：
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通讯作者：
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DOI：
10.1086/591461
发表时间：
2008-10-01
期刊：
The Journal of infectious diseases
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/0005-2787(76)90527-x
发表时间：
1976-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
DEAMER, D;BANGHAM, AD
通讯作者：
BANGHAM, AD
影响因子：
2.4
作者：
Burt, SA;Reinders, RD
通讯作者：
Reinders, RD