Extranodal NK/T-Cell Lymphoma, Nasal Type: Genetic, Biologic, and Clinical Aspects with a Central Focus on Epstein-Barr Virus Relation.
Extranodal NK/T-Cell Lymphoma, Nasal Type: Genetic, Biologic, and Clinical Aspects with a Central Focus on Epstein-Barr Virus Relation.
复制标题
鼻外NK/T细胞淋巴瘤，鼻类型：遗传，生物学和临床方面，主要关注爱泼斯坦 - 巴尔病毒关系。
DOI：
10.3390/microorganisms9071381
复制
发表时间：
2021-06-25
期刊：
影响因子：
4.5
通讯作者：
Harabuchi Y
中科院分区：
文献类型：
--
作者：
Takahara M;Kumai T;Kishibe K;Nagato T;Harabuchi Y
鼻型结外NK/T细胞淋巴瘤（ENKTL-NT）有一些突出的方面。该淋巴瘤常见于东亚，在鼻腔有进行性坏死病变，使面中部破坏性病变，预后差。淋巴瘤细胞来源于表达CD 56的NK细胞或γδ T细胞。自从作者首次证明淋巴瘤细胞中存在EB病毒（EBV）DNA和EBV致癌蛋白以来，ENKTL-NT已被认为是EBV相关的恶性肿瘤。由于血管中心性和多形性淋巴瘤细胞与坏死背景上的炎性细胞混合，ENKTL-NT的诊断需要CD 56免疫染色和EBER原位杂交。此外，血清EBVDNA水平对ENKTL-NT的诊断和监测也有一定意义。尽管ENKTL-NT是难治性淋巴瘤，但通过开发诸如伴随放化疗的疗法来改善预后。基础研究表明，多种细胞内/细胞表面分子、细胞因子、趋化因子和microRNA参与了淋巴瘤的发生，其中一些与EBV相关。了解淋巴瘤的行为引入了新的治疗策略，如使用免疫检查点抑制剂，肽疫苗和分子靶向治疗。本文就ENKTL-NT的基础和临床研究进展，特别是其与EBV特征的关系作一综述。
Extranodal NK/T-Cell Lymphoma, nasal type (ENKTL-NT) has some salient aspects. The lymphoma is commonly seen in Eastern Asia, has progressive necrotic lesions in the nasal cavity, makes midfacial destructive lesions, and shows poor prognosis. The lymphoma cell is originated from either NK- or γδ T-cells, which express CD56. Since the authors first demonstrated the existence of Epstein–Barr virus (EBV) DNA and EBV oncogenic proteins in lymphoma cells, ENKTL-NT has been recognized as an EBV-associated malignancy. Because the angiocentric and polymorphous lymphoma cells are mixed with inflammatory cells on a necrotic background, the diagnosis of ENKTL-NT requires CD56 immunostaining and EBER in situ hybridization. In addition, serum the EBV DNA level is useful for the diagnosis and monitoring of ENKTL-NT. Although ENKTL-NT is refractory lymphoma, the prognosis is improved by the development of therapies such as concomitant chemoradiotherapy. The basic research reveals that a wide variety of intracellular/cell surface molecules, cytokines, chemokines, and micro RNAs are involved in lymphomagenesis, and some of them are related to EBV. Understanding lymphoma behavior introduces new therapeutic strategies, such as the usage of immune checkpoint inhibitors, peptide vaccines, and molecular targeting therapy. This review addresses recent advances in basic and clinical aspects of ENKTL-NT, especially its relation to EBV features.
登录
查看更多内容
影响因子：
4.7
作者：
Endo, R;Yoshioka, M;Kobayashi, K
通讯作者：
Kobayashi, K
影响因子：
5.6
作者：
Gaal, K;Sun, NCJ;Arber, DA
通讯作者：
Arber, DA
影响因子：
5.6
作者：
Gualco, Gabriela;Domeny-Duarte, Pollyanna;Bacchi, Carlos E.
通讯作者：
Bacchi, Carlos E.
影响因子：
4.9
作者：
Gonzalez-Alvaro, Isidoro;Dominguez-Jimenez, Carmen;Ortiz, Ana M;Nunez-Gonzalez, Vanessa;Roda-Navarro, Pedro;Fernandez-Ruiz, Elena;Sancho, David;Sanchez-Madrid, Francisco
通讯作者：
Sanchez-Madrid, Francisco
影响因子：
45.3
作者：
Cheson, Bruce D.;Fisher, Richard I.;Lister, T. Andrew
通讯作者：
Lister, T. Andrew