Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri.

Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri.
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DOI:
10.1126/science.1188800
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发表时间:
2010-07-09
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Rokhsar DS
Rokhsar DS
中科院分区:
其他
文献类型:
--
作者:
Prochnik SE;Umen J;Nedelcu AM;Hallmann A;Miller SM;Nishii I;Ferris P;Kuo A;Mitros T;Fritz-Laylin LK;Hellsten U;Chapman J;Simakov O;Rensing SA;Terry A;Pangilinan J;Kapitonov V;Jurka J;Salamov A;Shapiro H;Schmutz J;Grimwood J;Lindquist E;Lucas S;Grigoriev IV;Schmitt R;Kirk D;Rokhsar DS

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多细胞绿藻Volvox carteri 及其形态多样的近亲(Volvocine 藻类)非常适合研究多细胞进化和发育。我们对 V. carteri 的 138 兆碱基对基因组进行了测序,并将其约 14,500 个预测蛋白质与其单细胞亲戚莱茵衣藻的蛋白质进行了比较。尽管在生物体复杂性和生活史方面存在根本差异,但这两个物种具有相似的蛋白质编码潜力,并且很少有物种特异性蛋白质编码基因预测。 Volvox 富含 volvocine 藻类特异性蛋白质,包括与扩展且高度分隔的细胞外基质相关的蛋白质。我们的分析表明,生物体复杂性的增加可能与谱系特异性蛋白质的修饰有关,而不是与蛋白质编码能力的大规模发明有关。
The multicellular green alga Volvox carteri and its morphologically diverse close relatives (the volvocine algae) are well suited for the investigation of the evolution of multicellularity and development. We sequenced the 138–mega–base pair genome of V. carteri and compared its ~14,500 predicted proteins to those of its unicellular relative Chlamydomonas reinhardtii. Despite fundamental differences in organismal complexity and life history, the two species have similar protein-coding potentials and few species-specific protein-coding gene predictions. Volvox is enriched in volvocine-algal–specific proteins, including those associated with an expanded and highly compartmentalized extracellular matrix. Our analysis shows that increases in organismal complexity can be associated with modifications of lineage-specific proteins rather than large-scale invention of protein-coding capacity.
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