Evolution of an expanded sex-determining locus in Volvox.

Evolution of an expanded sex-determining locus in Volvox.
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DOI:
10.1126/science.1186222
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发表时间:
2010-04-16
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Umen JG
Umen JG
中科院分区:
其他
文献类型:
--
作者:
Ferris P;Olson BJ;De Hoff PL;Douglass S;Casero D;Prochnik S;Geng S;Rai R;Grimwood J;Schmutz J;Nishii I;Hamaji T;Nozaki H;Pellegrini M;Umen JG

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虽然两性异形在多细胞真核生物中反复进化,但它们的起源仍不清楚。交配位点(MT)的性二态多细胞绿色鱼,团藻carteri,指定生产的卵子和精子,并经历了显着的扩张和分歧相对于MT从莱茵衣藻,一个密切相关的单细胞物种,具有相同大小的配子。转录组分析揭示了团藻MT基因相对于衣原体的重新连接的配子表达程序,并确定了多个性别特异性和性别调节的转录本。成视网膜细胞瘤肿瘤抑制基因同源物MAT3是团藻MT基因,显示性调节的选择性剪接和性别特异性选择的证据,两者都表明进入性周期的共选择。因此,性别决定基因座影响性别相关和非性别相关基因的进化。
Although dimorphic sexes have evolved repeatedly in multicellular eukaryotes, their origins are unknown. The mating locus (MT) of the sexually dimorphic multicellular green alga, Volvox carteri, specifies the production of eggs and sperm and has undergone a remarkable expansion and divergence relative to MT from Chlamydomonas reinhardtii, a closely related unicellular species that has equal-sized gametes. Transcriptome analysis revealed a rewired gametic expression program for Volvox MT genes relative to Chlamydomonas, and identified multiple gender-specific and sex-regulated transcripts. The retinoblastoma tumor suppressor homolog MAT3 is a Volvox MT gene that displays sexually regulated alternative splicing and evidence of gender-specific selection, both indicative of cooption into the sexual cycle. Thus, sex-determining loci impact the evolution of both sex-related and non-sex-related genes.
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