Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials.
Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials.
复制标题
DOI：
10.1001/archneurol.2011.94
复制
发表时间：
2011-05
影响因子：
--
通讯作者：
Sperling, Reisa A.
中科院分区：
文献类型：
--
作者：
Atri, Alireza;O'Brien, Jacqueline L.;Sreenivasan, Aishwarya;Rastegar, Sarah;Salisbury, Sibyl;DeLuca, Amy N.;O'Keefe, Kelly M.;LaViolette, Peter S.;Rentz, Dorene M.;Locascio, Joseph J.;Sperling, Reisa A.
探讨编码任务功能磁共振成像（fMRI）在轻度阿尔茨海默病（AD）中的可行性和重测信度。随机、双盲、安慰剂对照（RCT）研究。记忆临床实验组。12名患有轻度AD（MMSE 24.0±0.7，CDR 1）的受试者，接受>6个月稳定的多奈哌齐，来自较大的24周研究的安慰剂组（n=24，在第0、6、12、24周进行四次扫描）。安慰剂和三个面孔-姓名配对关联编码，12周内的区块设计BOLD-fMRI扫描。全脑t图（p<0.001，5-连续体素）和海马感兴趣区域（ROI）分析新大于重复（N>R）面名对比度的范围（EXT，%活跃体素）和幅度（MAG，%信号变化）。海马ROI的类内相关性（ICC）和功效估计的计算。任务耐受性和数据产量很高（96次扫描中有95次产生高质量数据）。全脑图谱稳定。右侧和左侧海马ROI ICC分别为0.59-0.87和0.67-0.74。使用L/R-EXT或R-MAG以80%把握度（双侧-α=0.05）检测0-12周海马活动的25-50%变化需要14-51例受试者。由于相对较小的信号方差比，使用L-MAG需要>125名受试者。编码任务功能磁共振成像成功地实施了一个单一的网站，24周，AD随机对照试验。第0-12周的全脑t图是稳定的，重测信度的海马功能磁共振成像测量范围从中度到大量。在杠杆化背景下，右坎普-MAG可能是这些候选指标中最有希望的。这些初步估计的重测信度和权力证明评价编码任务功能磁共振成像作为一个潜在的生物标志物的“信号效应”在轻度AD的探索性和概念验证试验。这些结果的验证与更大的样本量和评估在多个网站的研究是必要的。
To examine feasibility and test-retest reliability of encoding-task functional MRI (fMRI) in mild Alzheimer’s disease (AD). Randomized, double-blind, placebo-controlled (RCT) study. Memory clinical trials unit. Twelve subjects with mild AD (MMSE 24.0±0.7, CDR 1), on >6 months stable donepezil, from the placebo-arm of a larger 24-week (n=24, four scans on weeks 0,6,12,24) study. Placebo and three face-name paired-associate encoding, block-design BOLD-fMRI scans in 12 weeks. Whole-brain t-maps (p<0.001, 5-contiguous voxels) and hippocampal regions-of-interest (ROI) analyses of extent (EXT, %voxels active) and magnitude (MAG, %signal change) for Novel-greater-than-Repeated (N>R) face-name contrasts. Calculation of Intraclass Correlations (ICC) and power estimates for hippocampal ROIs. Task-tolerability and data yield were high (95 of 96 scans yield good quality data). Whole-brain maps were stable. Right and left hippocampal ROI ICCs were 0.59–0.87 and 0.67–0.74, respectively. To detect 25–50% changes in 0–12 week hippocampal activity using L/R-EXT or R-MAG with 80% power (2-sided-α=0.05) requires 14–51 subjects. Using L-MAG requires >125 subjects due to relatively small signals to variance ratios. Encoding-task fMRI was successfully implemented in a single-site, 24-week, AD RCT. Week 0–12 whole-brain t-maps were stable and test-retest reliability of hippocampal fMRI measures ranged from moderate to substantial. Right hippocampal-MAG may be the most promising of these candidate measures in a leveraged context. These initial estimates of test-retest reliability and power justify evaluation of encoding-task fMRI as a potential biomarker for “signal-of-effect” in exploratory and proof-of-concept trials in mild AD. Validation of these results with larger sample sizes and assessment in multi-site studies is warranted.
登录
查看更多内容
影响因子：
11
作者：
Miller, S. L.;Fenstermacher, E.;Dickerson, B. C.
通讯作者：
Dickerson, B. C.
影响因子：
16.2
作者：
Lustig, C;Buckner, RL
通讯作者：
Buckner, RL
DOI：
10.1073/pnas.2235925100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Lustig, C;Snyder, AZ;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
4.2
作者：
Poldrack, Russell A.
通讯作者：
Poldrack, Russell A.
影响因子：
2.7
作者：
FLEISS, JL;COHEN, J
通讯作者：
COHEN, J