Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
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DOI：
10.1038/ng.2560
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发表时间：
2013-04
期刊：
影响因子：
30.8
通讯作者：
Easton, Douglas F.
中科院分区：
文献类型：
--
作者：
Eeles, Rosalind A.;Al Olama, Ali Amin;Benlloch, Sara;Saunders, Edward J.;Leongamornlert, Daniel A.;Tymrakiewicz, Malgorzata;Ghoussaini, Maya;Luccarini, Craig;Dennis, Joe;Jugurnauth-Little, Sarah;Dadaev, Tokhir;Neal, David E.;Hamdy, Freddie C.;Donovan, Jenny L.;Muir, Ken;Giles, Graham G.;Severi, Gianluca;Wiklund, Fredrik;Gronberg, Henrik;Haiman, Christopher A.;Schumacher, Fredrick;Henderson, Brian E.;Le Marchand, Loic;Lindstrom, Sara;Kraft, Peter;Hunter, David J.;Gapstur, Susan;Chanock, Stephen J.;Berndt, Sonja I.;Albanes, Demetrius;Andriole, Gerald;Schleutker, Johanna;Weischer, Maren;Canzian, Federico;Riboli, Elio;Key, Tim J.;Travis, Ruth C.;Campa, Daniele;Ingles, Sue A.;John, Esther M.;Hayes, Richard B.;Pharoah, Paul D. P.;Pashayan, Nora;Khaw, Kay-Tee;Stanford, Janet L.;Ostrander, Elaine A.;Signorello, Lisa B.;Thibodeau, Stephen N.;Schaid, Dan;Maier, Christiane;Vogel, Walther;Kibel, Adam S.;Cybulski, Cezary;Lubhiski, Jan;Cannon-Albright, Lisa;Brenner, Hermann;Park, Jong Y.;Kaneva, Radka;Batra, Jyotsna;Spurdle, Amanda B.;Clements, Judith A.;Teixeira, Manuel R.;Dicks, Ed;Lee, Andrew;Dunning, Alison M.;Baynes, Caroline;Conroy, Don;Maranian, Melanie J.;Ahmed, Shahana;Govindasami, Koveela;Guy, Michelle;Wilkinson, Rosemary A.;Sawyer, Emma J.;Morgan, Angela;Dearnaley, David P.;Horwich, Alan;Huddart, Robert A.;Khoo, Vincent S.;Parker, Christopher C.;Van As, Nicholas J.;Woodhouse, Christopher J.;Thompson, Alan;Dudderidge, Tim;Ogden, Chris;Cooper, Colin S.;Lophatananon, Artitaya;Cox, Angela;Southey, Melissa C.;Hopper, John L.;English, Dallas R.;Aly, Markus;Adolfsson, Jan;Xu, Jiangfeng;Zheng, Siqun L.;Yeager, Meredith;Kaaks, Rudolf;Diver, W. Ryan;Gaudet, Mia M.;Stern, Mariana C.;Corral, Roman;Joshi, Amit D.;Shahabi, Ahva;Wahlfors, Tiina;Tammela, Teuvo L. J.;Auvinen, Anssi;Virtamo, Jarmo;Klarskov, Peter;Nordestgaard, Borge G.;Roder, M. Andreas;Nielsen, Sune F.;Bojesen, Stig E.;Siddiq, Afshan;FitzGerald, Liesel M.;Kolb, Suzanne;Kwon, Erika M.;Karyadi, Danielle M.;Blot, William J.;Zheng, Wei;Cai, Qiuyin;McDonnell, Shannon K.;Rinckleb, Antje E.;Drake, Bettina;Colditz, Graham;Wokolorczyk, Dominika;Stephenson, Robert A.;Teerlink, Craig;Muller, Heiko;Rothenbacher, Dietrich;Sellers, Thomas A.;Lin, Hui-Yi;Slavov, Chavdar;Mitev, Vanio;Lose, Felicity;Srinivasan, Srilakshmi;Maia, Sofia;Paulo, Paula;Lange, Ethan;Cooney, Kathleen A.;Antoniou, Antonis C.;Vincent, Daniel;Bacot, Francois;Tessier, Daniel C.;Kote-Jarai, Zsofia;Easton, Douglas F.
前列腺癌是发达国家男性中最常见的癌症。为了鉴定常见的前列腺癌易感等位基因，我们在来自国际PRACTICAL联盟的25，074例前列腺癌病例和24，272例对照的血液DNA中，在定制的Illumina阵列（iCOGS）上对211，155个SNP进行了基因分型。23个新的前列腺癌易感基因位点在全基因组显著性（P < 5 × 10−8）。超过70个前列腺癌易感基因座，解释了这种疾病的家族风险的30%，现已确定。根据新的和以前已知的风险位点所赋予的综合风险，风险分布的前1%的风险比被分析的人群的平均风险高4.7倍。这些结果将有助于临床研究的人群风险分层。
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10−8). More than 70 prostate cancer susceptibility loci, explaining ~30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
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影响因子：
9.8
作者：
ENCODE Project Consortium
通讯作者：
ENCODE Project Consortium
影响因子：
5.3
作者：
Kote-Jarai Z;Amin Al Olama A;Leongamornlert D;Tymrakiewicz M;Saunders E;Guy M;Giles GG;Severi G;Southey M;Hopper JL;Sit KC;Harris JM;Batra J;Spurdle AB;Clements JA;Hamdy F;Neal D;Donovan J;Muir K;Pharoah PD;Chanock SJ;Brown N;Benlloch S;Castro E;Mahmud N;O'Brien L;Hall A;Sawyer E;Wilkinson R;Easton DF;Eeles RA
通讯作者：
Eeles RA
中国男性全基因组关联研究确定了 9q31.2 和 19q13.4 两个新的前列腺癌风险位点
影响因子：
30.8
作者：
Xu J;Mo Z;Ye D;Wang M;Liu F;Jin G;Xu C;Wang X;Shao Q;Chen Z;Tao Z;Qi J;Zhou F;Wang Z;Fu Y;He D;Wei Q;Guo J;Wu D;Gao X;Yuan J;Wang G;Xu Y;Wang G;Yao H;Dong P;Jiao Y;Shen M;Yang J;Ou-Yang J;Jiang H;Zhu Y;Ren S;Zhang Z;Yin C;Gao X;Dai B;Hu Z;Yang Y;Wu Q;Chen H;Peng P;Zheng Y;Zheng X;Xiang Y;Long J;Gong J;Na R;Lin X;Yu H;Wang Z;Tao S;Feng J;Sun J;Liu W;Hsing A;Rao J;Ding Q;Wiklund F;Gronberg H;Shu XO;Zheng W;Shen H;Jin L;Shi R;Lu D;Zhang X;Sun J;Zheng SL;Sun Y
通讯作者：
Sun Y
影响因子：
4.2
作者：
Callen, David F.;Ricciardelli, Carmela;Holm, Ruth
通讯作者：
Holm, Ruth
DOI：
10.1056/nejmoa1110000
发表时间：
2012-01-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ewing CM;Ray AM;Lange EM;Zuhlke KA;Robbins CM;Tembe WD;Wiley KE;Isaacs SD;Johng D;Wang Y;Bizon C;Yan G;Gielzak M;Partin AW;Shanmugam V;Izatt T;Sinari S;Craig DW;Zheng SL;Walsh PC;Montie JE;Xu J;Carpten JD;Isaacs WB;Cooney KA
通讯作者：
Cooney KA