Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways.
Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways.
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应激性酒精摄入的性别差异：杏仁核和炎症途径临床前研究综述
DOI：
10.1007/s00213-022-06120-w
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发表时间：
2022-07
影响因子：
3.4
通讯作者：
Picciotto, Marina R.
中科院分区：
文献类型：
--
作者：
Mineur, Yann S.;Garcia-Rivas, Vernon;Thomas, Merrilee A.;Soares, Alexa R.;McKee, Sherry A.;Picciotto, Marina R.
临床研究表明，女性比男性更有可能因压力而再次饮酒，但这种性别差异背后的机制尚不清楚。许多临床前行为模型已被用来研究压力引起的酒精摄入。在这里，我们回顾了用于研究压力对啮齿类动物酒精摄入量影响的范式，重点关注与性别差异相关的发现。迄今为止，关于压力引起的饮酒的性别差异的研究还比较有限，然而，有证据表明以杏仁核为中心的回路有助于压力对饮酒的影响。此外，我们概述了导致小胶质细胞激活的炎症途径，这可能有助于酒精依赖行为。我们提出，以杏仁核为中心的神经元功能和炎症信号传导的性别差异与压力引起的寻酒行为的性别依赖性影响有关，并表明这是未来研究的一个重要领域。
Clinical studies suggest that women are more likely than men to relapse to alcohol drinking in response to stress, however the mechanisms underlying this sex difference are not well understood. A number of preclinical behavioral models have been used to study stress-induced alcohol intake. Here we review paradigms used to study effects of stress on alcohol intake in rodents, focusing on findings relevant to sex differences. To date, studies of sex differences in stress-induced alcohol drinking have been somewhat limited, however, there is evidence that amygdala-centered circuits contribute to effects of stress on alcohol seeking. In addition, we present an overview of inflammatory pathways leading to microglial activation that may contribute to alcohol-dependent behaviors. We propose that sex differences in neuronal function and inflammatory signaling in circuits centered on the amygdala are involved in sex-dependent effects on stress-induced alcohol seeking and suggest that this is an important area for future studies.
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